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. 2025 Jul 2:85:103304.
doi: 10.1016/j.eclinm.2025.103304. eCollection 2025 Jul.

World health Organization's guidance for tracking non-communicable diseases towards sustainable development goals 3.4: an initiative for facility-based monitoring

Arlene Quiambao  1 Mohammad-Reza Malekpour  2 Ali Golestani  2 Mahsa Heidari-Foroozan  2 Seyyed-Hadi Ghamari  2 Mohsen Abbasi-Kangevari  2 Benjamin O Anderson  1   3 Prebo Barango  1 Elena Fidarova  1 Bianca Hemmingsen  1 Andre Ilbawi  1 Taskeen Khan  1 Roberta Ortiz Sequeria  1 Gojka Roglic  1 Sarah Rylance  1 Felipe Roitberg  1 Leanne Riley  1 Slim Slama  1 Lubna Bhatti  1 Melanie Cowan  1 Patricia Rarau  1 Stefan Savin  1 Farshad Farzadfar  1 Kouamivi Mawuenyegan Agboyibor  4 Ashutosh N Aggarwal  5 Oyetayo Akala  1 Chaisiri Angkurawaranon  6 Hong Anh Chu  7 Ranjit Mohan Anjana  8 Carmen Antini  9 Zeba Aziz  10 Shannon Barkley  11 Abdul Basit  12 Partha Basu  13 Sara Benitez Majano  9 Kazi Bennoor  14 Jeffrey W Brettler  15 Neslihan Cabioglu  16 Roberta Caixeta  9 Norman Campbell  17 Carolina Chavez  9 Sohel Reza Choudhury  18 Marilys Anne Corbex  19 Alvaro Cruz  20 Nemdia Daceney  21 Shona Dalal  22 Goodarz Danaei  23 Jean-Marie Dangou  4 Wouter De Groote  1 Cheick Bady Diallo  4 Issimouha Dille  4 Rolando Enrique Domingo  24 Gampo Dorji  25 Brucel B Duncan  26 Uzochukwu Egere  27 Hicham El Berri  28 Asma El Sony  29 Mai Eltigani  1 Jill Farrington  19 Heba Fouad  27 Paola Friedrich  30 Soad Fuentes-Alabi  9 Angelo Gamarra  9 Edward Gregg  31 Reena Gupta  32 Sumit Gupta  33 Weiping Jia  34 Evelyn Jiagge  35 Pekka Jousilahti  36 Ratnasabathipillai Kesavan  25 Somesh Kumar  37 Tiina Laatikainen  38 Bagher Larijani  39 Maria Lasierra Losada  19 Tuyet Lan Le Thi  40 Naomi Levitt  41 Sylvana Luciani  9 Mauricio Maza  9 Bente Mikkelsen  1 Yousser Mohammad  42 Andrew Moran  43 Ali Motlagh  44 Stephen Mulupi  27 Raul H Murillo  45 Miriam Mutebi  46 Rebecca Nantanda  47 Moffat Nyirenda  48 Patrick O'Connor  49 Dike Ojji  50 Gertrude Edna Omoro  1 Dolores Ondarsuhu  9 Pedro Ordunez  9 Mohamed Ould Sidi Mohamed  4 Mayowa Owolabi  51 Kazem Rahimi  52 Ivo Rakovac  19 Joao Filipe Raposo  53 Andres Rosende  9 Jane Rowley  22 Rengaswamy Sankaranarayanan  54 Vitaly Smelov  19 Josaia Tiko  24 Marcello Tonelli  17 Elena Tsoyi  19 Todd Tuttle  55 Cherian Varghese  56 Liliana Vásquez  9 Kavitha Viswanathan  57 Hongyi Xu  1 Cheng-Har Yip  58
Affiliations

World health Organization's guidance for tracking non-communicable diseases towards sustainable development goals 3.4: an initiative for facility-based monitoring

Arlene Quiambao et al. EClinicalMedicine. .

Abstract

Background: Non-communicable diseases (NCDs) account for over 60% of annual global deaths, disproportionately affecting low- and middle-income countries. This trend undermines progress toward Sustainable Development Goal (SDG) 3.4, which seeks to reduce premature mortality from NCDs by one-third by 2030. Despite the availability of effective and relatively affordable interventions, addressing NCDs requires sustained, coordinated efforts and robust monitoring systems. Facility-based monitoring offers a dynamic alternative to static surveys, enabling continuous assessment of healthcare quality and utilization.

Methods: This study followed a systematic approach to develop standardized global and national NCD monitoring indicators, using the Donabedian model as a conceptual framework. It focused on four major NCD categories: hypertension and cardiovascular diseases (CVDs), diabetes, chronic respiratory diseases, and cancers. The methodology included systematic scoping reviews from inception up to November 2021 and a multi-round Delphi process involving global experts to assess the validity and feasibility of proposed indicators. This study was funded internally by WHO. There were no payments to participants.

Findings: The final output consisted of 81 validated indicators-22 core and 59 optional. These indicators demonstrated high feasibility and relevance for facility-based monitoring of NCD service delivery. They provide actionable metrics for assessing and improving the quality of care across diverse health system settings.

Interpretation: This study highlights the urgent need for comprehensive, context-sensitive NCD monitoring frameworks. The proposed set of indicators offers a validated foundation for improving NCD care delivery and aligns with efforts to achieve SDG target 3.4. Ongoing updates and local adaptations will be essential to ensure continued relevance and effectiveness.

Funding: This study was funded internally by WHO.

Keywords: Delphi technique; Health information systems; Noncommunicable diseases; Primary health care; Quality indicators; World Health Organization.

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Conflict of interest statement

Dr. Evelyn Jiagge has received institutional payments from Pfizer and Genentech via Henry Ford Health. Kazem Rahimi reports grants from the National Institute for Health Research (NIHR304997), Medical Research Council (MR/Y030419/1), British Heart Foundation (FS/PhD/22/29321, FS/PhD/21/29110, FS/PhD/25/29632), European Union (101080430), Roche (R94776/CN002), and Novo Nordisk Oxford Big Data Partnership. He receives personal royalties from Lucem Health and honoraria as Editor-in-Chief of Heart and for speaking engagements with Radcliffe Cardiology. He also serves on Medtronic’s Renal Denervation Advisory Board. Norm RC Campbell holds unpaid advisory roles with the World Hypertension League, HEARTS in the Americas (PAHO/WHO), and as Vice Chair of the Canadian Hypertension Coalition. Patrick J. O’Connor has received institutional grant support from the U.S. National Institutes of Health for research unrelated to this work. Sumit Gupta has received consulting fees and honoraria from Amgen for advisory work and lectures on the role of immunotherapy in acute lymphoblastic leukemia (ALL). Abdul Basit, Jean-Marie Dangou, Hicahm El Berri, Asma El Sony, Paola Friedrich, Soad Fuentes-Alabi, Ratnasabathipillai Kesavan, Bagher Larijani, Mauricio Maza, Gojka Roglic, Rengaswamy Sankaranarayanan, and Josaia Tiko were required to sign the Confidentiality Undertaking and Declaration of Interest forms via the WHO platform, which did not allow experts with any potential competing interests to participate in the panel meeting.

Figures

Fig. 1
Fig. 1
Flow chart of the final included studies in the review based on the PRISMA statement.
Fig. 2
Fig. 2
Average feasibility and validity scores of the 86 primary indicators during the Delphi process (Full names of the primary indicators are provided in the Supplementary Appendix 2). Panels: (A) Diabetes indicators; (B) Hypertension indicators; (C) Chronic respiratory diseases indicators; (D) Breast cancer indicators; (E) Cervical cancer indicators; (F) Childhood cancers indicators; (G) General cancers indicators.

References

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    1. Hearts D: diagnosis and management of type 2 diabetes. https://www.who.int/publications-detail-redirect/who-ucn-ncd-20.1

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