Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 18;25(1):518.
doi: 10.1186/s12872-025-05008-9.

Association between calcium intake and risk of congestive heart failure: a cross-sectional study from the 2003-2018 NHANES database

Bo Zhu #  1   2 , Li Wan #  3 , Xingyu Chen #  1 , Zihan Wang  4 , Haiwei Rao  5 , Qing Li  6 , Chen Huang  7
Affiliations

Association between calcium intake and risk of congestive heart failure: a cross-sectional study from the 2003-2018 NHANES database

Bo Zhu et al. BMC Cardiovasc Disord. .

Abstract

Background: Congestive heart failure (CHF) is a critical condition resulting from impaired blood pumping, leading to fluid accumulation. While calcium plays a vital role in skeletal health and muscle contraction, its potential in preventing CHF remains unclear.

Objectives: This study aimed to investigate the relationship between calcium intake and the risk of CHF using data from the National Health and Nutrition Examination Survey (NHANES) collected between 2003 and 2018.

Methods: After completing the questionnaire, participants were classified into CHF and control groups, with calcium intake considered as the primary exposure variable, alongside categorical factors such as age and race. Statistical analyses included t-tests and chi-square tests. A subsequent risk stratification analysis assessed the impact of various covariates on CHF. Additionally, Least Absolute Shrinkage and Selection Operator (LASSO) regression was applied to identify optimal predictor variables, and model performance was evaluated using the receiver operating characteristic curve.

Results: A total of 3,083 participants were included in the study. Baseline characteristics revealed significant differences in race (p = 0.004), education (p = 0.019), fasting glucose (p = 0.047), and calcium intake (p = 0.020) between the CHF and control groups. In model 3, calcium intake was significantly associated with a reduced risk of CHF (p < 0.001, OR = 6.37 × 10-4, 95% CI = 1.47 × 10-4 - 1.13 × 10-3), acting as a protective factor (OR < 1, 95% CI = 1 × 10-6 - 1 × 10-5). LASSO regression further identified calcium intake as a predictor variable.

Conclusion: Calcium intake serves as a protective factor against CHF, potentially lowering its risk. These findings provide theoretical support for the prevention and diagnosis of CHF.

Keywords: Calcium intake; Congestive heart failure; NHANES; Weighted multivariate logistic regression model.

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study involves human participants and was approved by NHANES was approved by the NCHS Research Ethics Review Board. Participants gave informed consent to participate in the study before taking part. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
A flowchart the inclusion and exclusion criteria
Fig. 2
Fig. 2
Associations between dietary calcium intake and the risk of CHF. A Weighted multivariate logistic regression analysis of dietary calcium and CHF risk. B Exposure factors ROC curve C LASSO model residual sum of squares plot and LASSO regression coefficient plot. D Constructing a column chart based on the seven best predictor variables E LASSO-ROC curve. AUC: Area under curve; BMI: Body mass index; LASSO: Least absolute shrinkage and selection operator; OR: Odds ratio
See this image and copyright information in PMC

References

    1. Chen J, Aronowitz P. Congestive heart failure. Med Clin North Am. 2022;106(3):447–58. 10.1016/j.mcna.2021.12.002. - PubMed
    1. Borlaug BA, Sharma K, Shah SJ, Ho JE. Heart failure with preserved ejection fraction: JACC scientific statement. J Am Coll Cardiol. 2023;81:1810–34. 10.1016/j.jacc.2023.01.049. - PubMed
    1. Ziaeian B, Fonarow GC. Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 2016;13:368–78. 10.1038/nrcardio.2016.25. - PMC - PubMed
    1. Felker GM, Ellison DH, Mullens W, Cox ZL, Testani JM. Diuretic therapy for patients with heart failure: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75:1178–95. 10.1016/j.jacc.2019.12.059. - PubMed
    1. Scicchitano P, Iacoviello M, Passantino A, et al. Plasma levels of intact parathyroid hormone and congestion burden in heart failure: clinical correlations and prognostic role. J Cardiovasc Dev Dis. 2022;9(10):334. 10.3390/jcdd9100334. - PMC - PubMed

Substances

LinkOut - more resources