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Comment
. 2025 Jul 18;29(1):311.
doi: 10.1186/s13054-025-05567-5.

Missing the target in target trial emulation: the authors reply

Ryan Ruiyang Ling  1   2   3 , Ying Chen  4 , Kiran Shekar  5   6   7   8 , Daniel Brodie  9 , Graeme MacLaren  1   10 , Kollengode Ramanathan  11   12
Affiliations
Comment

Missing the target in target trial emulation: the authors reply

Ryan Ruiyang Ling et al. Crit Care. .
No abstract available

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: RRL receives research support from the Clinician Scientist Development Unit, Yong Loo Lin School of Medicine, National University of Singapore. He serves as a fellow of the Extracorporeal Life Support Organisation (ELSO) Scientific Oversight Committee, and is an editorial board member of Critical Care. DB reports consulting for LivaNova. He has been on the medical advisory boards for Medtronic, Inspira, Cellenkos and HBOX Therapies. He participates on the Data Safety Monitoring Board for the Early mobilisation during extracorporeal membrane oxygenation (ECMO-PT) study. He is the President of ELSO and the Chair of the Board of ECMONet, and he writes for UpToDate. GM is the Past President of ELSO. KR is the chair of the ELSO Publications Committee, and serves as a member and the past-chair of the ELSO Scientific Oversight Committee. All other authors declare no competing interests.

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References

    1. Urner M, Fan E. Missing the target in target trial emulation. Crit Care. 2025;29:266. 10.1186/s13054-025-05515-3. - PMC - PubMed
    1. Ling RR, Chen Y, Low CJW, Agerstrand C, Jung JS, Lim SL, et al. Left ventricular unloading during extracorporeal cardiopulmonary resuscitation: a target trial emulation of the ELSO registry. Crit Care. 2025;29(1):186. - PMC - PubMed
    1. Ling RR, Ramanathan K, Poon WH, Tan CS, Brechot N, Brodie D, et al. Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis. Crit Care. 2021;25(1):246. - PMC - PubMed
    1. Poon WH, Ramanathan K, Ling RR, Yang IX, Tan CS, Schmidt M, et al. Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care. 2021;25(1):292. - PMC - PubMed
    1. Ling RR, Ramanathan K, Sim JJL, Wong SN, Chen Y, Amin F, et al. Evolving outcomes of extracorporeal membrane oxygenation during the first 2 years of the COVID-19 pandemic: a systematic review and meta-analysis. Crit Care. 2022;26(1):147. - PMC - PubMed

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