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. 2025 Jul 19;37(1):223.
doi: 10.1007/s40520-025-03122-4.

Central and peripheral arterial stiffness and sarcopenia in hospitalized older adults

Francesco Fantin  1 , Serena Nicolussi Paolaz  2 , Anna Giani  3 , Elisa Mattachini  3 , Elena Zoico  3 , Mauro Zamboni  3
Affiliations

Central and peripheral arterial stiffness and sarcopenia in hospitalized older adults

Francesco Fantin et al. Aging Clin Exp Res. .

Abstract

Objective: Both sarcopenia and arterial wall stiffening are frequent findings among hospitalized older adults, and further insight should be gained to explore their pathophysiological mechanisms and possible correlations.

Methods: 90 hospitalized geriatric patients (mean age 83.94 ± 6.6 years, 38.89% female, 36.7% sarcopenic) have been enrolled, and underwent clinical, comorbidity and biochemical assessment. Sarcopenia was investigated following the diagnostic algorithm according to European guidelines assessing muscular strength, using a portable dynamometer, and muscle mass by bio-impedance analysis (BIA); carotid-femoral pulse wave velocity (cfPWV), carotid-radial PWV (crPWV), femoral-pedal PWV (fpPWV) and cardio-ankle vascular index (CAVI) were obtained for each.

Results: Sarcopenic patients (n = 33) were older (p < 0.01) than subjects without sarcopenia (n = 57). Sarcopenic patients presented higher CAVI (12.67 ± 3.12 vs. 10.91 ± 1.4, p < 0.01) and fpPWV, but not cfPWV and crPWV. In backward analysis muscle strength and comorbidity index resulted good indipendent variables of fpPWV (R2 0.11), muscle strength, comorbidity index and sex could predict CAVI (R2 0.22). When examining sarcopenia diagnoses determinants, in a logistic binary regression model and considering several possible covariates, fpPWV resulted a significant indipendent variable of sarcopenia along with age and sex.

Conclusion: increased indexes of arterial stiffness are shown in sarcopenic hospitalized older adults as compared to hospitalized patients without sarcopenia; peripheral arterial segments of the lower limb appeared to be more involved in the stiffening process, as compared to central segments.

Keywords: Arterial stiffness; Cardio-ankle vascular index; Femoral-pedal pulse wave velocity; Peripheral arterial stiffness; Sarcopenia.

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Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
(left): comparison of fpPWV in patients with and without sarcopenia, before (plain colour) and after (striped) adjustment for age, sex, arterial hypertension and Charlson Comorbidity Index; (right) comparison of CAVI in patients with and without sarcopenia, before (plain colour) and after (striped) adjustment for age, sex, arterial hypertension and Charlson Comorbidity Index. fpPWV: femoral-pedal pulse wave velocity; CAVI: Cardio Ankle Vascular Index
See this image and copyright information in PMC

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