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Review
. 2025 Oct:96:102568.
doi: 10.1016/j.ceb.2025.102568. Epub 2025 Jul 19.

Leveraging phylogenetic diversity: Cellular dynamics in non-model organisms

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Free article
Review

Leveraging phylogenetic diversity: Cellular dynamics in non-model organisms

Sarah L Guest et al. Curr Opin Cell Biol. 2025 Oct.
Free article

Abstract

Cell biologists use a severely undersampled population of eukaryotes as model organisms to infer cellular processes across an immense diversity. In consequence, mechanisms are defined in only a few lineages. Here, we highlight cellular behaviors not observed in model organisms. We describe examples (multicellular and protistan) from several major supergroups (TSAR, Haptista, Archaeplastida, Amorphea, Excavates), focusing on species for which quantified dynamic measurements are available. Through these examples, we discuss how these behaviors and underlying dynamics matter for the cell biology community. We aim to increase the awareness of such organisms and familiarize readers with the diversity of behaviors present in nature. By expanding the bestiary of organisms available to researchers, we can obtain a better picture of eukaryotic cells' features and capabilities.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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