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Case Reports
. 2025 Jul 4;12(3):100206.
doi: 10.1016/j.acpath.2025.100206. eCollection 2025 Jul-Sep.

Educational Case: Squamous cell carcinoma

Ashley R Scholl  1 , Melina B Flanagan  2 , Andrew D Thompson  3
Affiliations
Case Reports

Educational Case: Squamous cell carcinoma

Ashley R Scholl et al. Acad Pathol. .
No abstract available

Keywords: Pathology competencies; malignant skin neoplasms; organ system pathology; skin; squamous cell carcinoma.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
H&E, 40x. This is a shave biopsy demonstrating solar elastosis (black arrow) and an epithelial proliferation in the dermis.
Fig. 2
Fig. 2
H&E, 200x. This is a biopsy demonstrating neoplastic cells with abundant eosinophilic cytoplasm, prominent nucleoli, and large, pleomorphic nuclei.
Fig. 3
Fig. 3
H&E. 200x. This is a biopsy demonstrating neoplastic cells with keratin formation deep in the dermis.
Fig. 4
Fig. 4
H&E, 100x. Numerous keratin pearls are present.
Fig. 5
Fig. 5
H&E, 200x. This biopsy demonstrates extensively sun-damaged skin, as evidenced by solar elastosis.
Fig. 6
Fig. 6
H&E, 100x. Biopsy demonstrating basal cell carcinoma. Basaloid tumor cells are arranged in nests with peripheral palisading of cells, with a mucinous stroma, and retraction of tumor cells away from the stroma. Normal sebaceous glands are present in the lower portion of the image.
Fig. 7
Fig. 7
H&E, 200x. Biopsy demonstrating squamous cell carcinoma in situ. Atypical keratinocytes extend full-thickness throughout the epidermis. Note the solar elastosis and chronic inflammation in the dermis.
Fig. 8
Fig. 8
H&E, 40x. This is a biopsy demonstrating invasive squamous cell carcinoma with atypical keratinocytes invading into the dermis.
See this image and copyright information in PMC

References

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