Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 13;5(5):100551.
doi: 10.1016/j.bpsgos.2025.100551. eCollection 2025 Sep.

No Laughing Matter: Nitrous Oxide and Depression

Affiliations

No Laughing Matter: Nitrous Oxide and Depression

Ella Williams et al. Biol Psychiatry Glob Open Sci. .
No abstract available

PubMed Disclaimer

Similar articles

References

    1. Jevtović-Todorović V., Todorović S.M., Mennerick S., Powell S., Dikranian K., Benshoff N., et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med. 1998;4:460–463. - PubMed
    1. McIntyre R.S., Rosenblat J.D., Nemeroff C.B., Sanacora G., Murrough J.W., Berk M., et al. Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: An international expert opinion on the available evidence and implementation. Am J Psychiatry. 2021;178:383–399. - PMC - PubMed
    1. Nagele P., Duma A., Kopec M., Gebara M.A., Parsoei A., Walker M., et al. Nitrous oxide for treatment-resistant major depression: A proof-of-concept trial. Biol Psychiatry. 2015;78:10–18. - PubMed
    1. Nagele P., Palanca B.J., Gott B., Brown F., Barnes L., Nguyen T., et al. A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med. 2021;13 - PubMed
    1. Myles P.S., Kulkarni J., Kasza J., Wallace S., Deng C., Turbić A., et al. Antidepressant effects of nitrous oxide in major depressive disorder: A phase 2b randomized clinical trial. Biol Psychiatry Glob Open Sci. 2025;5 - PMC - PubMed

LinkOut - more resources