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. 2025 Jun 13;5(5):100551.
doi: 10.1016/j.bpsgos.2025.100551. eCollection 2025 Sep.

No Laughing Matter: Nitrous Oxide and Depression

Ella Williams  1 , Philip J Cowen  1   2
Affiliations

No Laughing Matter: Nitrous Oxide and Depression

Ella Williams et al. Biol Psychiatry Glob Open Sci. .
No abstract available

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References

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    1. Nagele P., Duma A., Kopec M., Gebara M.A., Parsoei A., Walker M., et al. Nitrous oxide for treatment-resistant major depression: A proof-of-concept trial. Biol Psychiatry. 2015;78:10–18. - PubMed
    1. Nagele P., Palanca B.J., Gott B., Brown F., Barnes L., Nguyen T., et al. A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med. 2021;13 - PubMed
    1. Myles P.S., Kulkarni J., Kasza J., Wallace S., Deng C., Turbić A., et al. Antidepressant effects of nitrous oxide in major depressive disorder: A phase 2b randomized clinical trial. Biol Psychiatry Glob Open Sci. 2025;5 - PMC - PubMed

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