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Editorial
. 2025 Jun 30;17(6):3484-3486.
doi: 10.21037/jtd-2025-690. Epub 2025 Jun 12.

Is early transcatheter aortic valve replacement for asymptomatic aortic stenosis justified?-critical analysis of the strategy

Aurelien Gonze  1 , Thibault Gennart  1 , Emily Perriens  2 , Sydney Blackman  3 , Nathan De Lissnyder  4 , Arnaud Robert  1 , Julien Moury  1 , Gauthier Nendumba  1 , Benedicte Hauquiert  1 , Priscilla Gillis  1 , Ovidiu Vornicu  5 , Anne-Sophie Dincq  5 , Pierre Bulpa  1 , Isabelle Michaux  1 , Patrick M Honore  1
Affiliations
Editorial

Is early transcatheter aortic valve replacement for asymptomatic aortic stenosis justified?-critical analysis of the strategy

Aurelien Gonze et al. J Thorac Dis. .
No abstract available

Keywords: Asymptomatic severe aortic stenosis; clinical surveillance; early transcatheter aortic valve replacement (early TAVR); mortality; stroke.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2025-690/coif). The authors have no conflicts of interest to declare.

Comment on

  • Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis.
    Généreux P, Schwartz A, Oldemeyer JB, Pibarot P, Cohen DJ, Blanke P, Lindman BR, Babaliaros V, Fearon WF, Daniels DV, Chhatriwalla AK, Kavinsky C, Gada H, Shah P, Szerlip M, Dahle T, Goel K, O'Neill W, Sheth T, Davidson CJ, Makkar RR, Prince H, Zhao Y, Hahn RT, Leipsic J, Redfors B, Pocock SJ, Mack M, Leon MB; EARLY TAVR Trial Investigators. Généreux P, et al. N Engl J Med. 2025 Jan 16;392(3):217-227. doi: 10.1056/NEJMoa2405880. Epub 2024 Oct 28. N Engl J Med. 2025. PMID: 39466903 Clinical Trial.

References

    1. Généreux P, Schwartz A, Oldemeyer JB, et al. Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis. N Engl J Med 2025;392:217-27. 10.1056/NEJMoa2405880 - DOI - PubMed
    1. Kang DH, Park SJ, Lee SA, et al. Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis. N Engl J Med 2020;382:111-9. 10.1056/NEJMoa1912846 - DOI - PubMed
    1. Banovic M, Putnik S, Da Costa BR, et al. Aortic valve replacement vs. conservative treatment in asymptomatic severe aortic stenosis: long-term follow up of the AVATAR trial. Eur Heart J 2024;45:4526-35. 10.1093/eurheartj/ehae585 - DOI - PubMed
    1. Mack MJ, Leon MB, Thourani VH, et al. Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years. N Engl J Med 2023;389:1949-60. 10.1056/NEJMoa2307447 - DOI - PubMed
    1. Landmesser U. The Changing Landscape of Aortic-Valve Stenosis Management. N Engl J Med 2023;389:2008-9. 10.1056/NEJMe2311826 - DOI - PubMed

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