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. 2025 Jul 17:15357597251352993.
doi: 10.1177/15357597251352993. Online ahead of print.

Getting STAT-isfaction

Helen E Scharfman  1   2
Affiliations

Getting STAT-isfaction

Helen E Scharfman. Epilepsy Curr. .
No abstract available

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Figures

Figure 1.
Figure 1.
STAT3 signaling and its resurgence during epileptogenesis. (A) A diagram of the JAK/STAT pathway is shown with Ezh2 as a prominent regulator. After binding of ligands such as cytokines and growth factors, the receptor for the ligand is phosphorylated by JAK, making the receptor a docking site for STAT3. JAKs phosphorylate STATs, leading to their dimerization and translocation to the nucleus where they act on target genes. Created in BioRender. . (B) A diagram of the mouse model of TLE used by the authors to study levels of STAT3. SE was induced and 1 day later STAT3 levels were high, followed by a decline by day 4. After 14 weeks they found STAT3 was elevated again, suggesting a resurgence. (1) One explanation of resurgence is that during epileptogenesis something occurs that triggers an elevation of STAT3 and that initiates the first seizure. Here STAT3 plays a pivotal role in the transition to spontaneous recurrent seizures. (2) Another explanation is that the first seizure during the phase of chronic epilepsy triggers an elevation of STAT3, which might recur every time there is a seizure. Here STAT3 is not necessarily critical but simply associated with the chronic phase of epilepsy.
See this image and copyright information in PMC

References

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