Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 6:21:70-72.
doi: 10.1016/j.jdin.2025.03.004. eCollection 2025 Aug.

Superior performance of two combined polygenic scores for predicting skin cancer risk and differentiating risk of melanoma from keratinocyte carcinomas in two cohorts

Luzheng Liu  1   2   3 , Huy Tran  4 , Ashley J Mulford  5 , Zhuqing Shi  4 , Jun Wei  4 , Annabelle Ashworth  4 , S Lilly Zheng  4 , Jason B Waldinger  1   2 , Ross M Levy  1   2 , Alan R Sanders  2   5 , Jianfeng Xu  2   4
Affiliations

Superior performance of two combined polygenic scores for predicting skin cancer risk and differentiating risk of melanoma from keratinocyte carcinomas in two cohorts

Luzheng Liu et al. JAAD Int. .
No abstract available

Keywords: family history; keratinocyte carcinoma (KC); melanoma; polygenic risk score; skin cancer.

PubMed Disclaimer

Conflict of interest statement

NorthShore University HealthSystem has agreements with GenomicMD for implementing genetic tests of polygenic scores in clinic. GenomicMD is not involved in study design, data analysis, and preparation of manuscript.

References

    1. Mucci L.A., Hjelmborg J.B., Harris J.R., et al. Familial risk and heritability of cancer among twins in nordic countries. JAMA. 2016;315(1):68–76. - PMC - PubMed
    1. Truong B., Hull L.E., Ruan Y., et al. Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases. Cell Genom. 2024;4(4) - PMC - PubMed
    1. Namba S., Saito Y., Kogure Y., et al. Common germline risk variants impact somatic alterations and clinical features across cancers. Cancer Res. 2023;83(1):20–27. - PMC - PubMed
    1. Bycroft C., Freeman C., Petkova D., et al. The UK Biobank resource with deep phenotyping and genomic data. Nature. 2018;562(7726):203–209. - PMC - PubMed
    1. David S.P., Dunnenberger H.M., Choi S., et al. Personalized medicine in a community health system: the NorthShore experience. Front Genet. 2023;14 - PMC - PubMed

LinkOut - more resources