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. 1977 Jun;15(5-6):439-44.
doi: 10.1007/BF00520189.

Purine nucleoside phosphorylase polymorphism in sheep erythrocytes

P G Board, J E Smith

Purine nucleoside phosphorylase polymorphism in sheep erythrocytes

P G Board et al. Biochem Genet. 1977 Jun.

Abstract

A polymorphism of purine nucleoside phosphorylase is described in sheep erythrocytes. Two isozymes were distinguished electrophoretically, one with high activity (NP-1) and one with low activity (NP-2). Breeding data suggest that the two isozymes are the product of two codominant alleles, NP1 and NP2. The Km's for inosine did not differ between NP-1 and NP-2; however, NP-2 had a lower pH optimum and was relatively unstable when incubated at 48 C.

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