Non-KPC Attributes of the Newer β-lactam/β-lactamase Inhibitors, Part 2: Burkholderia cepacia complex, Stenotrophomonas maltophilia, and Acinetobacter baumannii
- PMID: 40689850
- DOI: 10.1093/cid/ciaf403
Non-KPC Attributes of the Newer β-lactam/β-lactamase Inhibitors, Part 2: Burkholderia cepacia complex, Stenotrophomonas maltophilia, and Acinetobacter baumannii
Abstract
The BL/BLI combination drugs, ceftazidime/avibactam, meropenem/vaborbactam, and imipenem/relebactam, have proven especially useful for treating carbapenemase producing, carbapenem resistant organisms (CRO), specifically Klebsiella pneumoniae carbapenemases (KPCs). However, non-KPC mechanisms of resistance are rising in prevalence among Gram-negatives and are increasingly challenging to treat. These newer BL/BLIs, including sulbactam/durlobactam, have an array of activity against mechanisms of carbapenem resistance beyond KPC and therefore play an important role in the treatment of non-KPC CRO. This review, the second in a two-part series, lays out the non-KPC attributes of the newer BL/BLIs with a focus on clinical utility against Burkholderia cepacia complex, Stenotrophomonas maltophilia, Acinetobacter baumannii and other rare pathogens.
Keywords: aztreonam; ceftazidime/avibactam; imipenem/relebactam; meropenem/vaborbactam; sulbactam/durlobactam.
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