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Comment
. 2025 Jul 29;122(30):e2512734122.
doi: 10.1073/pnas.2512734122. Epub 2025 Jul 21.

An ancient immune pathway enables animal metamorphosis

Elizabeth Heath-Heckman  1   2
Affiliations
Comment

An ancient immune pathway enables animal metamorphosis

Elizabeth Heath-Heckman. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
Schematic of RNAi Method and Morphogenic Pathway Presented by Darin et al. Marine bacteria (Left) were engineered to express dsRNA and were then fed to experimental H. elegans larvae to decrease the expression of MyD88. Further analysis revealed that MyD88 is a part of the signaling cascade needed both for bacterial MACs to drive morphogenesis and to defend against death upon exposure to P. aeruginosa. The postulated pathway driving morphogenesis is shown, and two of the genes at bottom, IL17 and RUNX, were shown to be downregulated in MyD88-knockdown animals. Image credit: Adapted from ref. .
See this image and copyright information in PMC

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