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. 2025 Jul 21.
doi: 10.1038/s44321-025-00277-5. Online ahead of print.

PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors

Chiara Pozzi #  1 , Riccardo Sarti #  1   2 , Antonino Lo Cascio  1 , Stefanos Bonovas  1   2 , Luca Tiraboschi  1   2 , Michela Lizier  1 , Alice Bertocchi  1 , Rosalba Torrisi  1 , Bethania Fernandes  1 , Piergiuseppe Colombo  1   2 , Pietro Diana  1   2 , Emilia Maria Cristina Mazza  1 , Marina Valeri  1   2 , Salvatore Lorenzo Renne  1   2 , Ferdinando Carlo Maria Cananzi  1   2 , Laura Samà  1 , Alexia Bertuzzi  1 , Corrado Tinterri  1   2 , Massimo Lazzeri  1 , Maria Rescigno  3   4
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Free article

PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors

Chiara Pozzi et al. EMBO Mol Med. .
Free article

Abstract

Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a significant prognostic factor for metastasis-free survival in both luminal BC and ccRCC. Further research is needed to validate PV-1's prognostic utility, as including it at diagnosis may change the management of these patients and should allow stratification for more aggressive therapies or for closer follow-ups to promptly intervene in case of metastases development.

Keywords: Biomarker; Endothelial Permeability; Metastasis-free Survival; PV-1 (PLVAP); Solid Tumors.

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Conflict of interest statement

Disclosure and competing interests statement. Maria Rescigno is an EMM editorial board member, EMBO Member and EMBO Council Chair. This has no bearing on the editorial consideration of this article for publication. The remaining authors declare no competing interests.

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