Does ability and willingness to use continuous RRT improve patient outcomes? A few answers, plenty of questions and opportunities for research

doi:10.1007/s00134-025-08045-2

Editorial

. 2025 Jul 21.

doi: 10.1007/s00134-025-08045-2. Online ahead of print.

Does ability and willingness to use continuous RRT improve patient outcomes? A few answers, plenty of questions and opportunities for research

Stéphane Gaudry^{1

2

3}, John R Prowle^{4

5}, Michael Darmon^{6

7

8}

Affiliations

¹ Département de Réanimation Médico-Chirurgicale, AP-HP, Hôpital Avicenne, Université Sorbonne Paris Nord, Bobigny, France. stephanegaudry@gmail.com.
² Common and Rare Kidney Diseases, Sorbonne Université, INSERM, UMR-S 1155, Paris, France. stephanegaudry@gmail.com.
³ Health Care Simulation Centre, UFR SMBH, Université Sorbonne Paris Nord, Bobigny, France. stephanegaudry@gmail.com.
⁴ Critical Care and Peri-Operative Medicine Research Group, Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.
⁵ Adult Critical Care Unit, The Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, London, UK.
⁶ Saint-Louis University Hospital, Paris, France.
⁷ Université Paris Cité, Paris, France.
⁸ ICU People Research Group, UMR 1153, INSERM, Paris, France.

PMID: 40691372
DOI: 10.1007/s00134-025-08045-2

Editorial

Does ability and willingness to use continuous RRT improve patient outcomes? A few answers, plenty of questions and opportunities for research

Stéphane Gaudry et al. Intensive Care Med. 2025.

. 2025 Jul 21.

doi: 10.1007/s00134-025-08045-2. Online ahead of print.

Authors

Stéphane Gaudry^{1

2

3}, John R Prowle^{4

5}, Michael Darmon^{6

7

8}

Affiliations

¹ Département de Réanimation Médico-Chirurgicale, AP-HP, Hôpital Avicenne, Université Sorbonne Paris Nord, Bobigny, France. stephanegaudry@gmail.com.
² Common and Rare Kidney Diseases, Sorbonne Université, INSERM, UMR-S 1155, Paris, France. stephanegaudry@gmail.com.
³ Health Care Simulation Centre, UFR SMBH, Université Sorbonne Paris Nord, Bobigny, France. stephanegaudry@gmail.com.
⁴ Critical Care and Peri-Operative Medicine Research Group, Faculty of Medicine and Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.
⁵ Adult Critical Care Unit, The Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, London, UK.
⁶ Saint-Louis University Hospital, Paris, France.
⁷ Université Paris Cité, Paris, France.
⁸ ICU People Research Group, UMR 1153, INSERM, Paris, France.

PMID: 40691372
DOI: 10.1007/s00134-025-08045-2

No abstract available

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Conflict of interest statement

Declarations. Conflicts of interest: Dr. Darmon reports being a section editor of Intensive Care Medicine and that he had not participated to reviewing or decision process of the current manuscript. Dr Prowle has received honoraria for speaking or consultation from Vantive Inc, BBraun Melsungen AG and NorrDia AB. He did not participate in the reviewing or decision process of the current manuscript. Dr Gaudry has received grants from French ministry of health to perform clinical studies on RRT timing and RRT modalities. He participated to the reviewing process of the manuscript from Neyra and colleagues. Consent for publication: The final version of the manuscript has been approved by every of the authors. Ethical approval: Not applicable.

References

1. Gaudry S, Hajage D, Schortgen F et al (2016) Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med 375:122–133. https://doi.org/10.1056/NEJMoa1603017 - DOI - PubMed
1. Bagshaw S, Wald R, Adhikari N et al (2020) Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med 383:240–251. https://doi.org/10.1056/NEJMoa2000741 - DOI - PubMed
1. Barbar SD, Clere-Jehl R, Bourredjem A et al (2018) Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med 379:1431–1442. https://doi.org/10.1056/NEJMoa1803213 - DOI - PubMed
1. Bagshaw S, Neto A, Smith O et al (2022) Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med 48:1736–1750. https://doi.org/10.1007/s00134-022-06912-w - DOI - PubMed
1. Vinsonneau C, Camus C, Combes A et al (2006) Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet Lond Engl 368:379–385. https://doi.org/10.1016/S0140-6736(06)69111-3 - DOI

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[1] Gaudry S, Hajage D, Schortgen F et al (2016) Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med 375:122–133. https://doi.org/10.1056/NEJMoa1603017 - DOI - PubMed

[2] Gaudry S, Hajage D, Schortgen F et al (2016) Initiation strategies for renal-replacement therapy in the intensive care unit. N Engl J Med 375:122–133. https://doi.org/10.1056/NEJMoa1603017 - DOI - PubMed

[3] Bagshaw S, Wald R, Adhikari N et al (2020) Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med 383:240–251. https://doi.org/10.1056/NEJMoa2000741 - DOI - PubMed

[4] Bagshaw S, Wald R, Adhikari N et al (2020) Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med 383:240–251. https://doi.org/10.1056/NEJMoa2000741 - DOI - PubMed

[5] Barbar SD, Clere-Jehl R, Bourredjem A et al (2018) Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med 379:1431–1442. https://doi.org/10.1056/NEJMoa1803213 - DOI - PubMed

[6] Barbar SD, Clere-Jehl R, Bourredjem A et al (2018) Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med 379:1431–1442. https://doi.org/10.1056/NEJMoa1803213 - DOI - PubMed

[7] Bagshaw S, Neto A, Smith O et al (2022) Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med 48:1736–1750. https://doi.org/10.1007/s00134-022-06912-w - DOI - PubMed

[8] Bagshaw S, Neto A, Smith O et al (2022) Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial. Intensive Care Med 48:1736–1750. https://doi.org/10.1007/s00134-022-06912-w - DOI - PubMed

[9] Vinsonneau C, Camus C, Combes A et al (2006) Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet Lond Engl 368:379–385. https://doi.org/10.1016/S0140-6736(06)69111-3 - DOI

[10] Vinsonneau C, Camus C, Combes A et al (2006) Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trial. Lancet Lond Engl 368:379–385. https://doi.org/10.1016/S0140-6736(06)69111-3 - DOI

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Does ability and willingness to use continuous RRT improve patient outcomes? A few answers, plenty of questions and opportunities for research

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Does ability and willingness to use continuous RRT improve patient outcomes? A few answers, plenty of questions and opportunities for research

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