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. 2025 Jul 21.
doi: 10.1007/s12265-025-10652-9. Online ahead of print.

The Diagnostic Significance of Circulating Eicosanoid in Patients with Hypertrophic Cardiomyopathy

Yue Zhang  1 , Xinyu Liu  1 , Zhongze Zhang  1 , Weiyan Sun  1 , Wenjing Yue  1 , Le Liu  1 , Yi Zhu  1 , Xu Zhang  2 , Hong Wang  3
Affiliations

The Diagnostic Significance of Circulating Eicosanoid in Patients with Hypertrophic Cardiomyopathy

Yue Zhang et al. J Cardiovasc Transl Res. .

Abstract

Hypertrophic cardiomyopathy (HCM) is one of the most prevalent hereditary cardiovascular diseases. Eicosanoids are known to play a significant role in cardiovascular diseases and serve as biomarkers. In this study, plasma eicosanoids were profiled by LC-MS in a cohort of 78 healthy individuals and 73 patients diagnosed with HCM. Our findings reveal HCM patients exhibit downregulation of various eicosanoids, including AA, 5,6-DHET, 12-HETE, LXA4, EPA, etc. Notably, the combined predictive model incorporating 12-HETE and EPA demonstrates significant diagnostic value for HCM. Additionally, ten closely related metabolites showed significant positive correlations within the metabolic network graph. Eicosanoids such as 17,18-EEQ, LXA4, and 13-oxo-ODE exhibit significant negative correlations with plasma concentrations of hs-CRP and NT-proBNP in patients. Alterations in eicosanoid metabolism may be implicated in the pathophysiological processes underlying HCM.

Keywords: Biomarkers; Eicosanoids; Hypertrophic cardiomyopathy; Metabolomics.

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Conflict of interest statement

Declarations. Human Subjects/Informed Consent: The human studies were performed with the Huazhong University of Science and Technology Institutional Review Board Approval (TJ-C20181001) and abiding by the Declaration of Helsinki principles. Written informed consents were obtained from all patients and healthy volunteers. Conflicts of interest: The authors declare no conflicts of interest.

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