Microbiome and gartynecologic cancer

Bingqing Liao¹, Liang Chen¹, Jinghan Ruan², Renjie Wang¹, Bai Hu², Rui Long², Yan Li³, Guangmei Zhang⁴, Jing Yu⁵, Ming Zhang⁶, Yuanzhen Zhang⁷, Shujie Liao⁸

Affiliations

¹ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China.
² Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China.
³ Department of Gynecology and Obstetrics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
⁴ Department of Gynecology and Obstetrics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. Electronic address: guangmeizhang@126.com.
⁵ The Third Affiliated Hospital of Kunming Medical University, Kunming, China, Yunnan Cancer Center, Kunming, China. Electronic address: 774878940@qq.com.
⁶ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China; Clinical Research Center for Prenatal Diagnosis and Birth Health of Hubei Province, China; Clinical Research Center for Reproductive Science and Birth Health of Wuhan, Hubei Province, China. Electronic address: whu_mz@163.com.
⁷ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China; Clinical Research Center for Prenatal Diagnosis and Birth Health of Hubei Province, China; Clinical Research Center for Reproductive Science and Birth Health of Wuhan, Hubei Province, China. Electronic address: zhangyuanzhen@whu.edu.cn.
⁸ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China; Senior Department of Gynecology and Obstetrics, Chinese PLA General Hospital, Beijing, China; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China. Electronic address: liaosjmailbox@126.com.

PMID: 40692066
DOI: 10.1016/j.canlet.2025.217940

Review

Microbiome and gartynecologic cancer

Bingqing Liao et al. Cancer Lett. 2025.

. 2025 Jul 19:636:217940.

doi: 10.1016/j.canlet.2025.217940. Online ahead of print.

Authors

Bingqing Liao¹, Liang Chen¹, Jinghan Ruan², Renjie Wang¹, Bai Hu², Rui Long², Yan Li³, Guangmei Zhang⁴, Jing Yu⁵, Ming Zhang⁶, Yuanzhen Zhang⁷, Shujie Liao⁸

Affiliations

¹ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China.
² Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China.
³ Department of Gynecology and Obstetrics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
⁴ Department of Gynecology and Obstetrics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China. Electronic address: guangmeizhang@126.com.
⁵ The Third Affiliated Hospital of Kunming Medical University, Kunming, China, Yunnan Cancer Center, Kunming, China. Electronic address: 774878940@qq.com.
⁶ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China; Clinical Research Center for Prenatal Diagnosis and Birth Health of Hubei Province, China; Clinical Research Center for Reproductive Science and Birth Health of Wuhan, Hubei Province, China. Electronic address: whu_mz@163.com.
⁷ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China; Clinical Research Center for Prenatal Diagnosis and Birth Health of Hubei Province, China; Clinical Research Center for Reproductive Science and Birth Health of Wuhan, Hubei Province, China. Electronic address: zhangyuanzhen@whu.edu.cn.
⁸ Department of Obstetrics, Women's and Children's Hospital, Zhongnan Hospital of Wuhan University, Hubei Province, 430071, China; Senior Department of Gynecology and Obstetrics, Chinese PLA General Hospital, Beijing, China; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, China. Electronic address: liaosjmailbox@126.com.

PMID: 40692066
DOI: 10.1016/j.canlet.2025.217940

Abstract

In recent years more and more studies have pointed out that the microbiota plays an important role in the development of gynecological tumors. A healthy female reproductive tract microbiota is dominated by lactobacilli, which can produce lactic acid and other metabolites to protect the normal reproductive tract microenvironment. If the microflora is out of balance, the abnormally increased flora may contribute to inflammation and even cancer in the reproductive system by activating the immune response, regulating metabolites and hormone levels. In this review, we focus on the relationship between microbiota and three common gynecological cancers, namely cervical, endometrial and ovarian cancers, as well as the significance of microbes in the prevention, diagnosis, and treatment of these cancers, and we introduce the application of multi-omics techniques in microbes; finally, we analyze the common characteristics of microbes in gynecological cancers, and we propose the current challenges and future research directions.

Keywords: Cervical cancer; Endometrial cancer; Gynecological cancers; Microbiota; Multi-omics technologies; Ovarian cancer.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Microbiome and gartynecologic cancer

Affiliations

Microbiome and gartynecologic cancer

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

LinkOut - more resources

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