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. 2025 Jul 13:2025:8889232.
doi: 10.1155/ijog/8889232. eCollection 2025.

Distribution of Methylene Tetrahydrofolate Reductase Gene Polymorphisms in Women of Childbearing Age in Tai'an

Bo Zhou  1 , Chengzhen Gao  2   3 , Lirong Chen  4 , Yumei Wang  1 , Shufang Zhang  5 , Chao Hou  6 , Xiangyang An  7
Affiliations

Distribution of Methylene Tetrahydrofolate Reductase Gene Polymorphisms in Women of Childbearing Age in Tai'an

Bo Zhou et al. Int J Genomics. .

Abstract

Objective: The objective was to explore the distribution characteristics of methylenetetrahydrofolate reductase MTHFR 677C > T and 1298A > C gene polymorphisms among women of childbearing age in the Tai'an area. Method: A total of 243 women of childbearing age, the age ranged from 20 to 46 years, with a mean age of 31.0 ± 5.1 years, attending the Eugenics Clinic of Tai'an City Central Hospital between January 2018 and April 2019 were selected. The MTHFR 677C > T and 1298A > C gene polymorphisms were determined by fluorescence in situ hybridization. Result: Among 243 women of childbearing age, the MTHFR 677C > T genotype frequencies of CC, CT, and TT were 14.4%, 44.9%, and 40.7%, respectively, and the C and T Allele frequencies were 36.8% and 63.2%, respectively. The MTHFR 1298A > C genotype frequencies of AA, AC, and CC were 77.0%, 21.0%, and 2.0%, respectively. The A and C allele frequencies were 87.4% and 12.6%, respectively. The proportions of CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA, and TT/AC were 6.6%, 5.8%, 2.0%, 30.5%, 14.4%, 39.9%, and 0.8%. The proportion of women at moderate or severe risk of folic acid metabolism reached 87.6%. The MTHFR 677C > T gene mutation rate has obvious regional characteristics. Conclusion: The MTHFR 677C > T and 1298A > C gene polymorphisms in Tai'an were obvious. About 87.6% of women of childbearing age were at medium or high risk of folic acid utilization.

Keywords: gene polymorphism; methylenetetrahydrofolate reductase; women of childbearing age.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The proportion of different genotypes of MTHFR. (a) Distribution of MTHFR 677C > T genotypes in fertile females in Tai'an. (b) Distribution of MTHFR 1298A > C genotypes in fertile females in Tai'an. (c) Distribution of MTHFR 677C > T alleles in fertile females in Tai'an. (d) Distribution of MTHFR 1298A > C alleles in fertile females in Tai'an.
Figure 2
Figure 2
MTHFR gene polymorphisms in different regions. (a) Tree of MTHFR 677C > T mutation rate in different regions. (b) Bar graph of MTHFR 677C > T mutation rate in different regions. (c) Tree of MTHFR 1298A > C mutation rate in different regions. (d) Bar graph of MTHFR 1298A > C mutation rate in different regions.
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References

    1. Kinney M. O., Craig J. J., Delanty N. Folic Acid in Women With Epilepsy: Prescribing Advice. Practical Neurology . 2024;24(3):180–182. doi: 10.1136/pn-2023-003829. - DOI - PubMed
    1. Cui H., Zhang N., An J., et al. Maternal Folic Acid Supplementation to Prevent Preeclampsia: A Systematic Review and Meta-Analysis. Complementary Therapies in Medicine . 2024;82:p. 103052. doi: 10.1016/j.ctim.2024.103052. - DOI - PubMed
    1. Xu W., Yi L., Deng C., et al. Maternal Periconceptional Folic Acid Supplementation Reduced Risks of Non-Syndromic Oral Clefts in Offspring. Scientific Reports . 2021;11(1):p. 12316. doi: 10.1038/s41598-021-91825-9. - DOI - PMC - PubMed
    1. Qu Y., Lin S., Zhuang J., et al. First-Trimester Maternal Folic Acid Supplementation Reduced Risks of Severe and Most Congenital Heart Diseases in Offspring: A Large Case-Control Study. Journal of the American Heart Association . 2020;9(13) doi: 10.1161/JAHA.119.015652.e015652 - DOI - PMC - PubMed
    1. Zhang X., Liu J., Jin Y., et al. Folate of Pregnant Women After a Nationwide Folic Acid Supplementation in China. Maternal & Child Nutrition . 2019;15(4) doi: 10.1111/mcn.12828.e12828 - DOI - PMC - PubMed

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