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. 2025 Jul 7:12:1584799.
doi: 10.3389/fmed.2025.1584799. eCollection 2025.

Primary care patient and practice member perspectives on weight loss medications: challenges and opportunities

Jodi Summers Holtrop  1   2 , Caroline Tietbohl  1   2 , Leigh Perreault  3   4 , Lauri Connelly  1 , Peter C Smith  1 , Johnny Williams  1
Affiliations

Primary care patient and practice member perspectives on weight loss medications: challenges and opportunities

Jodi Summers Holtrop et al. Front Med (Lausanne). .

Abstract

Introduction: Obesity is a prevalent and concerning chronic condition; however, evidence-based interventions are available for treatment. With the arrival of newer and more effective anti-obesity medications, questions emerge regarding how these medicines can and should be used and how they affect the practice of primary care medicine. The objective of this study was to examine the many and intersecting factors affecting use and impact of these medicines.

Methods: Qualitative study of interviews with primary care practice members and their patients in one Colorado health system (n = 56 practices) over 3 years. Thematic analysis was used to triangulate responses from patients and practice members.

Results: Key themes from both practice members and patients were highly consistent revealing the following categories of benefits and burdens: (1) the new medicines are a "game changer" for practice and changed lives for patients, (2) there is significant burden for all in obtaining the medications for many patients, (3) not all patients should be on the medications, (4) the medications have changed the conceptualization of obesity for patients and providers, and practice teams, and (5) the availability of these medications have changed the practice of treating obesity in important ways. It was further identified that a cascade of events involving various factors with a "right fit" between the patient, provider, and other factors were needed to make way for access to and effective use of these medications.

Discussion: The arrival of highly effective weight loss medications may invigorate efforts to integrate weight management into primary care, but the implications of this shift are still unknown. Further exploration of the long-term effects on patients, providers and care paradigms is warranted.

Keywords: interviews; medication; patient perspectives; practice perspectives; primary care; weight loss.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Medication cascade of events.
See this image and copyright information in PMC

References

    1. Fryar C, Carroll M, Afful J. Prevalence of Overweight, Obesity, and Severe Obesity Among Adults Aged 20 and Over: United States, 1960–1962 Through 2017–2018. (2021). Available online at: https://www.cdc.gov/nchs/data/hestat/obesity-adult-17-18/obesity-adult.htm (accessed February 8, 2021)
    1. Bendix J, Lopez C. Economic Impact of Obesity Increased to $1.4 Trillion, Says Milken Institute. (2020). Available online at: https://milkeninstitute.org/content-hub/news-releases/economic-impact-ob... (accessed April 17, 2024).
    1. Kheniser K, Saxon D, Kashyap S. Long-term weight loss strategies for obesity. J Clin Endocrinol Metab. (2021) 106:1854–66. 10.1210/clinem/dgab091 - DOI - PMC - PubMed
    1. O’Brien P, Hindle A, Brennan L, Skinner S, Burton P, Smith A, et al. Long-term outcomes after bariatric surgery: A systematic review and meta-analysis of weight loss at 10 or more years for all bariatric procedures and a single-centre review of 20-year outcomes after adjustable gastric banding. Obes Surg. (2019) 29:3–14. 10.1007/s11695-018-3525-0 - DOI - PMC - PubMed
    1. Perreault L, Suresh K, Rodriguez C, Dickinson L, Willems E, Smith P, et al. Baseline characteristics of pathweigh: A stepped-wedge cluster randomized study for weight management in primary care. Ann Fam Med. (2023) 21:249–55. 10.1370/afm.2966 - DOI - PMC - PubMed

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