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Review
. 2025 Jul 22.
doi: 10.1007/s13312-025-00119-0. Online ahead of print.

Optimizing Influenza Vaccine Protection in India

Vipin M Vashishtha  1 , Puneet Kumar  2
Affiliations
Review

Optimizing Influenza Vaccine Protection in India

Vipin M Vashishtha et al. Indian Pediatr. .

Abstract

India is experiencing frequent outbreaks of seasonal influenza viruses, similar to the ongoing influenza type B in many states. Influenza viruses are linked to significant morbidity and mortality, particularly among children under 5 years of age. Despite the considerable burden of influenza and widespread surveillance throughout India, data on the true national burden is, at best, inconsistent. The year-round presence of influenza activity and two distinct peaks present significant challenges to India's single-dose annual influenza vaccination. This situation is further complicated by frequent vaccine updates due to ongoing 'antigenic drifts' in circulating influenza viruses and the short durability of most flu vaccines. This perspective briefly explores the strategies that can be implemented to maximize the benefits of the available vaccines.

Keywords: Antigenic drift; Durability of immunity; Universal flu vaccine; Vaccination.

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Conflict of interest statement

Declarations. Conflict of interest: None.

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References

    1. National Centre for Disease Control (NCDC), Delhi. Seasonal Influenza A (H1N1): State/UT-wise number of cases & deaths from 2019 to 2025 (As of 31.01.2025). Accessed on 16 March 2025. Available from: https://ncdc.mohfw.gov.in/wp-content/uploads/2025/03/Seasonal-Influenza-...
    1. Lavanya R. Swine flu cases surge in India: Over 20,000 infected, 347 deaths reported. Newsx [Internet]. Accessed on 16 Mar 2025. Available from: https://www.newsx.com/india/swine-flu-cases-surge-in-india-over-20000-in...
    1. Upadhyay A. Delhi sees surge in Influenza B, swine flu cases across age groups, say doctors. The Indian Express [Internet]. 2025 Mar 11. Accessed on 16 Mar 2025. Available from: https://indianexpress.com/article/cities/delhi/delhi-sees-surge-ininflue...
    1. Global Influenza Surveillance and Response System. Influenza laboratory surveillance information. Accessed on 27 May 2025. Available from: https://worldhealthorg.shinyapps.io/flunetchart/
    1. US Centres for Disease Control and Prevention. Types of influenza viruses. Accessed on 3 May 2025. Available from: https://www.cdc.gov/flu/about/viruses-types.html