doi: 10.1016/0304-3940(85)90587-7.
Cortical serotonin receptor subtypes after lesion of ascending cholinergic neurones in rat
- PMID: 4069435
- DOI: 10.1016/0304-3940(85)90587-7
Item in Clipboard
Cortical serotonin receptor subtypes after lesion of ascending cholinergic neurones in rat
Neurosci Lett.
.
Abstract
Serotonin (5-HT) S1 and S2 receptors were studied in rat cortex after lesion of the ascending cholinergic systems by injection of ibotenic acid into the nucleus basalis. The lesions produced a large (56%) decrease in choline acetyltransferase activity with no change in markers of gamma-aminobutyric acid, dopamine and 5-HT containing neurones. Lesions of the ascending cholinergic neurones were accompanied by a loss of 5-HT S1 receptor binding sites with no change in S2 receptors. These results suggest that a proportion of S1 receptors may be associated with cholinergic terminals.
Similar articles
-
Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex.Brain Res. 1985 May 6;333(2):345-9. doi: 10.1016/0006-8993(85)91590-2. Brain Res. 1985. PMID: 3995301
-
Recovery of neocortical choline acetyltransferase activity following ibotenic acid injection into the nucleus basalis of Meynert in rats.Brain Res. 1984 Feb 13;293(1):184-6. doi: 10.1016/0006-8993(84)91468-9. Brain Res. 1984. PMID: 6704718
-
Partial reversal of lesion-induced deficits in cortical cholinergic markers by nerve growth factor.Brain Res. 1986 Oct 29;386(1-2):397-9. doi: 10.1016/0006-8993(86)90179-4. Brain Res. 1986. PMID: 3779417
-
Maintenance of cortical somatostatin and monoamine levels in the rat does not require intact cholinergic innervation.Brain Res. 1987 Mar 17;406(1-2):326-9. doi: 10.1016/0006-8993(87)90801-8. Brain Res. 1987. PMID: 2436718
-
The current status of the cortical cholinergic system in Alzheimer's disease and Parkinson's disease.Prog Brain Res. 1986;70:105-32. doi: 10.1016/s0079-6123(08)64300-9. Prog Brain Res. 1986. PMID: 3554348 Review. No abstract available.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
