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. 1977 May;83(5):579-82.

[Change in the metabolism of 7,12-dimethylbenz(a)anthracene under the influence of vitamin A]

[Article in Russian]
K L Kkhandudzha, T D Esakova, B K Semin, Iu M Petrusevich, B N Tarusov
  • PMID: 406946

[Change in the metabolism of 7,12-dimethylbenz(a)anthracene under the influence of vitamin A]

[Article in Russian]
K L Kkhandudzha et al. Biull Eksp Biol Med. 1977 May.

Abstract

The in vitro metabolism of 7,12-dimethylbenz(a)anthracene in its incubation with the liver microsomes, the liver and mammary gland homogenates of rats, kept on vitamin A-enriched diet, was studied. Vitamin A inhibited the formation of lipophilic metabolites and increased the generation of water-soluble metabolites. The amount of lipophilic metabolites extracted from the microsomes and the liver and mammary gland homogenates were decreased by a factor of 2.2 and 5, respectively. The amount of unmetabolized DMBA in the liver microsomes was the same in control and experimental animals.

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