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. 2025 Jul 23;190(5):66.
doi: 10.1007/s11046-025-00977-z.

Topical Luliconazole Treatment for Hyperkeratotic Tinea Pedis

Sayaka Ohara  1 , Hiromitsu Noguchi  2   3 , Tadahiko Matsumoto  4   5 , Daiki Hayashi  6 , Kayo Kashiwada-Nakamura  6 , Masahide Kubo  4 , Rui Kano  7 , Satoshi Fukushima  6
Affiliations

Topical Luliconazole Treatment for Hyperkeratotic Tinea Pedis

Sayaka Ohara et al. Mycopathologia. .

Abstract

Chronic hyperkeratotic tinea pedis is a treatment-resistant infection. We evaluated the efficacy of a 3-month course of topical 1% luliconazole in 21 hyperkeratotic tinea pedis patients. The diagnosis was confirmed through microscopy and culture. The lesion area was assessed monthly using a software program. Clinical responses were classified into five categories from "cured" to "no change." Among the isolates, one terbinafine-resistant T. rubrum strain was detected. The mean lesion area decreased significantly over 3 months, with an average improvement rate of 94.1% ± 12.7% and a cure rate of 61.9%. The mean amount of luliconazole used per foot was 27.5 ± 9.7 g monthly. The resistant case showed a partial improvement with topical luliconazole and was successfully treated with oral fosravuconazole. These findings suggest that 1% topical luliconazole is effective for treating hyperkeratotic tinea pedis.

Keywords: Fosravuconazole; Hyperkeratotic tinea pedis; Luliconazole; Terbinafine-resistance.

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Conflict of interest statement

Declarations. Conflict of interest: This study was partially supported by funding from Iwaki Seiyaku Co., Ltd. The authors declare no other conflicts of interest. Ethics Approval: The study was approved by the Noguchi Dermatology Clinic ethics committee (approval No.49).

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