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Review
. 2024;13(4-6):169-173.
doi: 10.1080/20468954.2025.2535939. Epub 2025 Jul 22.

Trivalent bispecific anti-MSLN2/CD3 antibody for cancer treatment

Jorge Antonio Perez Saldaña  1 , Donaciano Flores-Robles  1 , Antonio Celestino Montes  1 , Alejandro Millán-Vega  1 , Pavel Sierra-Martínez  1 , Martin Perez-Santos  2
Affiliations
Review

Trivalent bispecific anti-MSLN2/CD3 antibody for cancer treatment

Jorge Antonio Perez Saldaña et al. Pharm Pat Anal. 2024.

Abstract

Introduction: Mesothelin protein is an overexpressed molecule in epithelioid mesothelioma, epithelial ovarian cancer, and pancreatic adenocarcinoma, which is why it is considered a potential therapeutic target.

Areas covered: WO2024082060 patent describes a trivalent bispecific antibody directed against MSLN/CD3/MSLN, and lung cancer treatment method. This antibody exhibits binding activity to MSLN-containing tumor cells, as well as inhibition of tumor growth rate in murine models of lung and ovarian cancer.

Expert opinion: The trispecific structure suggesting that this antibody is a potential candidate for clinical trials for the treatment of lung cancer associated with high levels of MSLN expression.

Keywords: CD3; MSLN; lung cancer; patent; trivalent bispecific antibody.

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Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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