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Review
. 2025 Jul 15;17(7):107681.
doi: 10.4251/wjgo.v17.i7.107681.

Advances and challenges in drug repurposing in precision therapeutics of colorectal cancer

Xin-Ning Yu  1 , Hua-Tao Wu  2 , Bing-Xuan Wu  2 , Shu-Feng Zhi  2 , Yang-Zheng Lan  1 , Wen-Jia Chen  1 , Jing Liu  3
Affiliations
Review

Advances and challenges in drug repurposing in precision therapeutics of colorectal cancer

Xin-Ning Yu et al. World J Gastrointest Oncol. .

Abstract

Colorectal cancer (CRC) ranks as the third most common cancer globally and the second leading cause of cancer-related deaths, representing a significant health burden. Despite advancements in traditional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, these approaches still face challenges, including high costs, limited efficacy, and drug resistance. Drug repurposing has emerged as a promising strategy for CRC treatment, offering advantages with reduced development timelines, lower costs, and improved drug accessibility. This review explores drug repurposing strategies for CRC, supported by multidisciplinary technologies, and discusses the current challenges in the field.

Keywords: Colorectal cancer; Drug repurposing; Multidisciplinary collaboration; Precision therapeutics; Treatment.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Multidisciplinary approach to drug repurposing, integrating real-world data, molecular biology, structural chemistry, computer science, and information biology.
See this image and copyright information in PMC

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