Comparative Study
doi: 10.1139/o77-086.
Oxidant effect of acetylphenylhydrazine: a comparative study with erythrocytes of several animal species
- PMID: 406973
- DOI: 10.1139/o77-086
Item in Clipboard
Comparative Study
Oxidant effect of acetylphenylhydrazine: a comparative study with erythrocytes of several animal species
Can J Biochem.
1977 Jun.
Abstract
Red cells from several animal species were treated with acetylphenylhydrazine and a comparative study of the oxidation of hemoglobin (Hb) and glutathione (GSH) made. Wide interspecies differences were observed but the oxidation of GSH paralleled that of Hb. Added glucose protected both Hb and GSH from oxidation; GSH by itself exercises a protective effect on Hb. The characteristic rates of oxidation of GSH in the different species can be observed only in the presence of oxyhemoglobin but not carboxyhemoblobin or methemoglobin. The oxidation of Hb appears to be the primary event, the oxidation of GSH being a consequence thereof.
Similar articles
-
Protective factors in the detoxication of hydrogen peroxide in erythrocytes.Can J Biochem. 1969 Apr;47(4):405-10. doi: 10.1139/o69-061. Can J Biochem. 1969. PMID: 4976782 No abstract available.
-
Cytologic demonstration of methemoglobin and carboxyhemoglobin in certain vertebrates.Am J Vet Res. 1972 May;33(5):1017-22. Am J Vet Res. 1972. PMID: 4112404 No abstract available.
-
Protection by ascorbate against acetylphenylhydrazine-induced Heinz body formation in glucose-6-phosphate dehydrogenase deficient erythrocytes.Br J Haematol. 1979 Feb;41(2):245-22. doi: 10.1111/j.1365-2141.1979.tb05853.x. Br J Haematol. 1979. PMID: 427033
-
Drug-induced oxidative denaturation of hemoglobin.Semin Hematol. 1973 Oct;10(4):269-78. Semin Hematol. 1973. PMID: 4610751 Review. No abstract available.
-
[Problem of the oxygenation of hemoglobin].Usp Fiziol Nauk. 1973 Jul-Sep;4(3):69-112. Usp Fiziol Nauk. 1973. PMID: 4616482 Review. Russian. No abstract available.
Cited by
-
Hemoglobin-glutathione relationships in trout erythrocytes treated with monochloramine.Bull Environ Contam Toxicol. 1982 Dec;29(6):637-44. doi: 10.1007/BF01606101. Bull Environ Contam Toxicol. 1982. PMID: 7159774 No abstract available.
-
High activity antioxidant enzymes protect flying-fox haemoglobin against damage: an evolutionary adaptation for flight?J Comp Physiol B. 2006 Nov;176(8):729-37. doi: 10.1007/s00360-006-0094-7. Epub 2006 Jun 7. J Comp Physiol B. 2006. PMID: 16758214
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources