Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 8:15:1581545.
doi: 10.3389/fcimb.2025.1581545. eCollection 2025.

Impact of free provision of disinfectant wipes combined with bundle management on the prevention of multi-drug resistant organism infections in the respiratory and intensive care unit

Yu-Dan Wang #  1 , Jian-Hong Liang #  2 , Xie-Nan Gao #  3 , Li-Li Ma  1 , Shen-Shen Huang  1 , Yong-Mei Zhang  1
Affiliations

Impact of free provision of disinfectant wipes combined with bundle management on the prevention of multi-drug resistant organism infections in the respiratory and intensive care unit

Yu-Dan Wang et al. Front Cell Infect Microbiol. .

Abstract

Objective: To explore the role of free provision of disinfectant wipes combined with bundle management in preventing Multi-Drug Resistant Organism (MDRO) infections in the Respiratory and Intensive Care Unit (RICU).

Methods: This study included patients admitted to the RICU between January 2022 and June 2023 (control group) and from July 2023 to June 2024 (intervention group), all of whom met the inclusion criteria. The control group received standard bundle management measures, while the intervention group received unlimited use of disinfectant wipes combined with bundle management. The MDRO discovery rates and hospital-acquired infection incidence rates were compared between the two groups to assess the impact of free disinfectant wipe provision on MDRO infection prevention in the RICU.

Results: There were no significant differences between the two groups in terms of patient age and baseline characteristics, except for Sex and the proportion of patients with chronic respiratory diseases. Notably, the MDRO discovery rate, MDRO infection rate, and hospital-acquired infection incidence were all significantly lower in the intervention group compared to the control group (MDRO discovery rate: 35.2% vs 45.9%, P<0.001; MDRO infection rate: 0.8% vs 3.5%, P = 0.003; hospital-acquired infection rate: 1.5% vs 3.52%, P=0.030). However, the intervention group had more percentage of patients receiving mechanical ventilation and longer ICU stay (P < 0.05). Furthermore, in-hospital mortality was lower in the intervention group (19.5% vs 13.5%, P < 0.05).

Conclusion: The combined intervention of unlimited use of disinfectant wipes with bundle management significantly reduced MDRO hospital-acquired infection rates and in-hospital mortality in the RICU, demonstrating its effectiveness in infection prevention.

Keywords: bundle management measures; disinfectant wipes; multi-drug resistant organisms; prevention; respiratory and intensive care unit.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Albaharna H., Almubiereek H., Almualim M., Bukhamsin R., Abdelfattah A., Buohliqah L. (2023). Efficacy of chlorin dioxide wipes in disinfecting airway devices contaminated with Covid-19. Front. Cell Infect. Microbiol. 13. doi: 10.3389/fcimb.2023.1061647, PMID: - DOI - PMC - PubMed
    1. Assefa M. (2022). Multi-drug resistant gram-negative bacterial pneumonia: etiology, risk factors, and drug resistance patterns. Pneumonia (Nathan) 14, 4. doi: 10.1186/s41479-022-00096-z, PMID: - DOI - PMC - PubMed
    1. Collaborators G. B. D. A. R. (2024). Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050. Lancet 404, 1199–1226. doi: 10.1016/S0140-6736(24)01867-1, PMID: - DOI - PMC - PubMed
    1. Dadon M., Chedid K., Martin E. T., Shaul I., Greiver O., Katz I., et al. (2023). The impact of bedside wipes in multi-patient rooms: a prospective, crossover trial evaluating infections and survival. J. Hosp Infect. 134, 50–56. doi: 10.1016/j.jhin.2022.11.025, PMID: - DOI - PubMed
    1. Ding D., Wang B., Zhang X., Zhang J., Zhang H., Liu X., et al. (2023). The spread of antibiotic resistance to humans and potential protection strategies. Ecotoxicol Environ. Saf. 254, 114734. doi: 10.1016/j.ecoenv.2023.114734, PMID: - DOI - PubMed

LinkOut - more resources