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Case Reports
. 2025 Jun 24;4(3):100526.
doi: 10.1016/j.jacig.2025.100526. eCollection 2025 Aug.

Monoclonal gammopathy in WHIM syndrome can mask hypogammaglobulinemia

Julia Lew  1 , Adil Adatia  2
Affiliations
Case Reports

Monoclonal gammopathy in WHIM syndrome can mask hypogammaglobulinemia

Julia Lew et al. J Allergy Clin Immunol Glob. .

Abstract

Monoclonal gammopathy can be seen at an early age in patients with warts-hypogammaglobulinemia, infections, and myelokathexis syndrome and can mask the presence of hypogammaglobulinemia.

Keywords: WHIM syndrome; immunoparesis; inborn error of immunity; monoclonal gammopathy; secondary hypogammaglobulinemia.

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Conflict of interest statement

Disclosure of potential conflict of interest: A. Adatia reports conference travel support, honararia, and/or clinical trial support from CSL Behring, Octapharma, and Takeda outside the submitted work. The remaining author declares no relevant conflicts of interest.

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References

    1. McDermott D.H., Murphy P.M. WHIM syndrome: immunopathogenesis, treatment and cure strategies. Immunol Rev. 2019;287:91–102. - PubMed
    1. Dotta L., Notarangelo L.D., Moratto D., Kumar R., Porta F., Soresina A., et al. Long-term outcome of WHIM syndrome in 18 patients: high risk of lung disease and HPV-related malignancies. J Allergy Clin Immunol Pract. 2019;7:1568–1577. - PubMed
    1. van de Donk N.W., Palumbo A., Johnsen H.E., Engelhardt M., Gay F., Gregersen H., et al. The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network. Haematologica. 2014;99:984–996. - PMC - PubMed
    1. Karafin M.S., Humphrey R.L., Detrick B. Evaluation of monoclonal and oligoclonal gammopathies in a pediatric population in a major urban center. Am J Clin Pathol. 2014;141:482–487. - PubMed
    1. Rikhi R., Bhattad S., Jindal A., Saikia B., Garg R., Rawat A., et al. Monoclonal gammopathy of unclear significance in a child with Wiskott-Aldrich syndrome: a rare occurrence. J Clin Immunol. 2019;39:7–10. - PubMed

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