Subnormothermic acellular machine perfusion for prolonged preservation of human kidneys

Affiliations

¹ Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.
² Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
³ Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
⁴ Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Sara Deffrennes et al. Br J Surg. 2025.

. 2025 Jul 3;112(7):znaf147.

doi: 10.1093/bjs/znaf147.

¹ Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.
² Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
³ Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
⁴ Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

No abstract available

Figures

1. Debout A, Foucher Y, Trébern-Launay K, Legendre C, Kreis H, Mourad G et al. Each additional hour of cold ischemia time significantly increases the risk of graft failure and mortality following renal transplantation. Kidney Int 2015;87:343–349 - PubMed
1. Nicholson ML, Hosgood SA. Renal transplantation after ex vivo normothermic perfusion: the first clinical study. Am J Transplant 2013;13:1246–1252 - PubMed
1. Hosgood SA, Callaghan CJ, Wilson CH, Smith L, Mullings J, Mehew J et al. Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial. Nat Med 2023;29:1511–1519 - PMC - PubMed
1. Arykbaeva AS, de Vries DK, Doppenberg JB, Engelse MA, Hankemeier T, Harms AC et al. Metabolic needs of the kidney graft undergoing normothermic machine perfusion. Kidney Int 2021;100:301–310 - PubMed
1. Abraham N, Gao Q, Kahan R, Alderete IS, Wang B, Howell DN et al. Subnormothermic oxygenated machine perfusion (24 h) in DCD kidney transplantation. Transplant Direct 2024;10:e1633. - PMC - PubMed