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Case Reports
. 2025 Jul 1;35(7):bhaf192.
doi: 10.1093/cercor/bhaf192.

The neural underpinnings of aphantasia: a case study of identical twins

Emma Megla  1 , Deepasri Prasad  2 , Wilma A Bainbridge  1   3
Affiliations
Case Reports

The neural underpinnings of aphantasia: a case study of identical twins

Emma Megla et al. Cereb Cortex. .

Abstract

Aphantasia is a condition characterized by reduced voluntary mental imagery. As this lack of mental imagery disrupts visual memory, understanding the nature of this condition can provide important insight into memory, perception, and imagery. Here, we leveraged the power of case studies to better characterize this condition by running a pair of identical twins, one with aphantasia and one without, through mental imagery tasks in a functional magnetic resonance imaging scanner. We identified objective, neural measures of aphantasia, finding less visual information in their memories, which may be due to lower connectivity between frontoparietal and occipitotemporal lobes of the brain. However, despite this difference, we surprisingly found more visual information in the aphantasic twin's memory than anticipated, suggesting that aphantasia is a spectrum rather than a discrete condition.

Keywords: fMRI; functional connectivity; long-term memory; perception; visual imagery.

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References

    1. Albers AM, Kok P, Toni I, Dijkerman HC, de Lange FP. 2013. Shared representations for working memory and mental imagery in early visual cortex. Curr Biol. 23:1427–1431. 10.1016/j.cub.2013.05.065. - DOI - PubMed
    1. Bainbridge WA, Baker CI. 2022. Multidimensional memory topography in the medial parietal cortex identified from neuroimaging of thousands of daily memory videos. Nat Commun. 13:6508. 10.1038/s41467-022-34075-1. - DOI - PMC - PubMed
    1. Bainbridge WA, Hall EH, Baker CI. 2021a. Distinct representational structure and localization for visual encoding and recall during visual imagery. Cereb Cortex. 31:1898–1913. 10.1093/cercor/bhaa329. - DOI - PMC - PubMed
    1. Bainbridge WA, Pounder Z, Eardley AF, Baker CI. 2021b. Quantifying aphantasia through drawing: those without visual imagery show deficits in object but not spatial memory. Cortex. 135:159–172. 10.1016/j.cortex.2020.11.014. - DOI - PMC - PubMed
    1. Baldassano C, Esteva A, Fei-Fei L, Beck DM. 2016. Two distinct scene-processing networks connecting vision and memory. eNeuro. 3:ENEURO.0178-16.2016. 10.1523/ENEURO.0178-16.2016. - DOI - PMC - PubMed

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