Mucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights

Mojca Bizjak^{1

2}, Daria Fomina^{3

4}, Jonny Peter^{5

6}, Ana Maria Giménez-Arnau⁷, David Pesqué⁸, Margarida Gonçalo⁹, Fernando Monteiro Aarestrup¹⁰, Dalia Melina Ahsan^{11

12}, Mona Al-Ahmad¹³, Sabine Altrichter^{11

12

14

15}, Gerelma Andrenova³, Andrea Bauer¹⁶, Elena Borzova¹⁷, Célia Costa¹⁸, Roberta Fachini Criado¹⁹, Semra Demir²⁰, Dejan Dinevski²¹, Luis Felipe Ensina²², Asli Gelincik²⁰, Maia Gotua²³, Jesper Grønlund Holm²⁴, Naoko Inomata²⁵, Maryam Khoshkhui²⁶, Aliya Klyucharova^{27

28}, Emek Kocatürk^{11

12

29}, Mitja Košnik^{1

2}, Kanokvalai Kulthanan³⁰, Eduardo M de Souza Lima¹⁰, Rongbiao Lu³¹, Michael Makris³², Raisa Meshkova³³, Maria Pasali³², Marisa Paulino¹⁸, German Dario Ramón³⁴, Carla Ritchie³⁵, Michael Rudenko³⁶, Simon Francis Thomsen²², Solange Oliveira Rodrigues Valle³⁷, Nicola Wagner³⁸, Paraskevi Xepapadaki³⁹, Xiaoyang Xue⁴⁰, Alicja Kasperska-Zajac⁴¹, Zuotao Zhao⁴², Dorothea Terhorst-Molawi^{11

12}

Affiliations

¹ Division of Allergy, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
² Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
³ Moscow Clinical and Research Center of Allergy and Immunology, State Hospital 52, Moscow Ministry of Healthcare, Moscow, Russian Federation.
⁴ Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
⁵ Division of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
⁶ Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
⁷ Dermatology Department, Hospital del Mar Research Institute, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ Dermatology Department, Hospital del Mar Research Institute, Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
⁹ Clinic of Dermatology, University Hospital, Coimbra Local Health Unit and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
¹⁰ Faculdade de Ciências, Médicas e da Saúde de Juiz de Fora (SUPREMA), Hospital Maternidade Therezinha de Jesus, Belo Horizonte, Brazil.
¹¹ Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
¹² Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Immunology and Allergology, Berlin, Germany.
¹³ Microbiology Department, Faculty of Medicine, Kuwait University, Safat, Kuwait.
¹⁴ Department of Dermatology and Venerology, Comprehensive Allergy Center, Kepler University Hospital, Linz, Austria.
¹⁵ Center for Medical Research, Johannes Kepler University, Linz, Austria.
¹⁶ Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany.
¹⁷ Dermatology Division, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
¹⁸ Immunoallergology Department, Hospital de Santa Maria, CHULN, Lisbon, Portugal.
¹⁹ Faculdade de Medicina do ABC (FMABC), Santo André, Brazil.
²⁰ Division of Allergy, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
²¹ Faculty of Medicine, University of Maribor, Maribor, Slovenia.
²² Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
²³ Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia.
²⁴ Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁵ Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
²⁶ Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
²⁷ City Center of Allergology and Immunology, City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, Russia.
²⁸ Department of Internal Diseases, Institute of Fundamental Medicine and Biology (IFMB) of Kazan Federal University, Kazan, Russia.
²⁹ Department of Dermatology, Bahçeşehir University, Istanbul, Turkey.
³⁰ Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
³¹ Department of Dermatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
³² Allergy Unit, Second Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens, Greece.
³³ Department of Clinical Immunology and Allergology, Smolensk State Medical University, Smolensk, Russian Federation.
³⁴ Instituto de Alergia e Inmunologia del Sur, Buenos Aires, Argentina.
³⁵ Adults and Pediatrics Allergy Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
³⁶ London Allergy and Immunology Centre, London, UK.
³⁷ Department of Internal Medicine, Immunology Service, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
³⁸ Department of Dermatology, Uniklinikum Erlangen, Friedrich Alexander University Erlangen-Nümberg (FAU), Erlangen, Germany.
³⁹ Allergy Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
⁴⁰ Department of General Practice, Community Health Service Center, Guangzhou City, China.
⁴¹ European Center for Diagnosis and Treatment of Urticaria/Angioedema (GA2LEN UCARE/ACARE Network) & Department of Clinical Allergology and Urticaria of Medical University of Silesia, Zabrze, Poland.
⁴² Department of Dermatology and Venerology, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, Peking University First Hospital, Beijing, China.

PMID: 40698997
DOI: 10.1111/jdv.20845

Mucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights

Mojca Bizjak et al. J Eur Acad Dermatol Venereol. 2026 Jan.

. 2026 Jan;40(1):e65-e70.

doi: 10.1111/jdv.20845. Epub 2025 Jul 23.

Authors

Affiliations

¹ Division of Allergy, University Clinic of Respiratory and Allergic Diseases Golnik, Golnik, Slovenia.
² Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
³ Moscow Clinical and Research Center of Allergy and Immunology, State Hospital 52, Moscow Ministry of Healthcare, Moscow, Russian Federation.
⁴ Department of Clinical Immunology and Allergology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
⁵ Division of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
⁶ Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa.
⁷ Dermatology Department, Hospital del Mar Research Institute, Universitat Pompeu Fabra (UPF), Barcelona, Spain.
⁸ Dermatology Department, Hospital del Mar Research Institute, Department of Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
⁹ Clinic of Dermatology, University Hospital, Coimbra Local Health Unit and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
¹⁰ Faculdade de Ciências, Médicas e da Saúde de Juiz de Fora (SUPREMA), Hospital Maternidade Therezinha de Jesus, Belo Horizonte, Brazil.
¹¹ Institute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
¹² Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Immunology and Allergology, Berlin, Germany.
¹³ Microbiology Department, Faculty of Medicine, Kuwait University, Safat, Kuwait.
¹⁴ Department of Dermatology and Venerology, Comprehensive Allergy Center, Kepler University Hospital, Linz, Austria.
¹⁵ Center for Medical Research, Johannes Kepler University, Linz, Austria.
¹⁶ Department of Dermatology, University Allergy Center, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany.
¹⁷ Dermatology Division, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
¹⁸ Immunoallergology Department, Hospital de Santa Maria, CHULN, Lisbon, Portugal.
¹⁹ Faculdade de Medicina do ABC (FMABC), Santo André, Brazil.
²⁰ Division of Allergy, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
²¹ Faculty of Medicine, University of Maribor, Maribor, Slovenia.
²² Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil.
²³ Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia.
²⁴ Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
²⁵ Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
²⁶ Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
²⁷ City Center of Allergology and Immunology, City Clinical Hospital No. 7 named after M.N. Sadykov, Kazan, Russia.
²⁸ Department of Internal Diseases, Institute of Fundamental Medicine and Biology (IFMB) of Kazan Federal University, Kazan, Russia.
²⁹ Department of Dermatology, Bahçeşehir University, Istanbul, Turkey.
³⁰ Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
³¹ Department of Dermatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
³² Allergy Unit, Second Department of Dermatology and Venereology, National and Kapodistrian University of Athens, University General Hospital "Attikon", Athens, Greece.
³³ Department of Clinical Immunology and Allergology, Smolensk State Medical University, Smolensk, Russian Federation.
³⁴ Instituto de Alergia e Inmunologia del Sur, Buenos Aires, Argentina.
³⁵ Adults and Pediatrics Allergy Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
³⁶ London Allergy and Immunology Centre, London, UK.
³⁷ Department of Internal Medicine, Immunology Service, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
³⁸ Department of Dermatology, Uniklinikum Erlangen, Friedrich Alexander University Erlangen-Nümberg (FAU), Erlangen, Germany.
³⁹ Allergy Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
⁴⁰ Department of General Practice, Community Health Service Center, Guangzhou City, China.
⁴¹ European Center for Diagnosis and Treatment of Urticaria/Angioedema (GA2LEN UCARE/ACARE Network) & Department of Clinical Allergology and Urticaria of Medical University of Silesia, Zabrze, Poland.
⁴² Department of Dermatology and Venerology, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses and National Clinical Research Center for Skin and Immune Diseases, Peking University First Hospital, Beijing, China.

PMID: 40698997
DOI: 10.1111/jdv.20845

No abstract available

Keywords: anaphylaxis; angioedema; cold urticaria; skin tests; urticaria.

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References

REFERENCES

1. Bizjak M, Rutkowski K, Asero R. Risk of anaphylaxis associated with cold Urticaria. Curr Treat Options Allergy. 2024;11(3):167–175.
1. Ornek Ozdemir S, Kuteyla Can P, Degirmentepe EN, Cure K, Singer R, Kocaturk E. A comparative analysis of chronic inducible urticaria in 423 patients: clinical and laboratory features and comorbid conditions. J Eur Acad Dermatol Venereol. 2024;38(3):513–520.
1. Bizjak M, Kosnik M, Terhorst‐Molawi D, Dinevski D, Maurer M. Cold agglutinins and Cryoglobulins associate with clinical and laboratory parameters of cold Urticaria. Front Immunol. 2021;12:665491.
1. Jain SV, Mullins RJ. Cold urticaria: a 20‐year follow‐up study. J Eur Acad Dermatol Venereol. 2016;30(12):2066–2071.
1. Bizjak M, Kosnik M, Dinevski D, Thomsen SF, Fomina D, Borzova E, et al. Risk factors for systemic reactions in typical cold urticaria: results from the COLD‐CE study. Allergy. 2022;77(7):2185–2199.

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Mucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights

Affiliations

Mucosal angioedema involving the oropharynx signals severe cold urticaria: COLD-CE study insights

Authors

Affiliations

References

REFERENCES

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources