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. 2025 Jul 23.
doi: 10.1007/s00508-025-02569-9. Online ahead of print.

Emerging antimicrobial resistance and high prevalence of genital Mycoplasma hominis and Ureaplasma urealyticum infections among infertile women in Algeria : Implications for reproductive health

Assia Mairi  1 , Nasir Adam Ibrahim  2 , Thagrawla Idres  3 , Nosiba S Basher  2 , Ahlam Smaili  1 , Takfarinas Idres  4 , Abdelaziz Toutati  1
Affiliations

Emerging antimicrobial resistance and high prevalence of genital Mycoplasma hominis and Ureaplasma urealyticum infections among infertile women in Algeria : Implications for reproductive health

Assia Mairi et al. Wien Klin Wochenschr. .

Abstract

Background: Genital infections caused by Mycoplasma hominis and Ureaplasma urealyticum are increasingly linked to female infertility, yet their epidemiology and resistance patterns remain poorly characterized in low-resource settings.

Objective: This study aimed to determine the prevalence, antimicrobial resistance (AMR) profiles, and risk factors of M. hominis and U. urealyticum infections among infertile women in Akbou, Algeria.

Methods: In this cross-sectional analysis (February-July 2024), cervicovaginal swabs from 79 infertile women were tested using the MYCOFAST® RevolutioN 2 system. Demographic, clinical, and reproductive data were collected via structured questionnaires. Statistical analyses included χ2-testsand logistic regression.

Results: The overall infection prevalence was 37.9% (n = 30), with U. urealyticum (17.7%), M. hominis (13.9%), and co-infections (6.3%) predominating. Infections peaked in women aged 31-35 years (63.3%). Resistance to tetracycline was high (U. urealyticum: 71.4%; M. hominis: 54.5%), while doxycycline and clindamycin retained full efficacy. Significant risk factors included prior abortion (adjusted odds ratio, OR = 4.2, p < 0.001), STI history (OR = 3.8, p < 0.001), and artificial insemination (OR = 2.9, p = 0.018).

Conclusion: The high prevalence of genital Mycoplasma infections and emerging AMR in Algeria underscores the need for routine screening, updated treatment guidelines, and targeted antimicrobial stewardship programs to safeguard reproductive health.

Keywords: Algeria; Female infertility; M. hominis; Reproductive risk factors; U. urealyticum.

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Conflict of interest statement

Declarations. Conflict of interest: A. Mairi, N.A. Ibrahim, T. Idres, N.S. Basher, A. Smaili, T. Idres and A. Toutati declare that they have no competing interests. Ethical standards: Institutional Review Board Statement. The experimental protocol was approved by the ethics committee of our university (N°Ethi/UMMTO/26-MAR-2024). Informed Consent Statement. Informed consent was obtained from all subjects involved in the study.

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