Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jun 25;42(2):16126.
doi: 10.36141/svdld.v42i2.16126.

Pulmonary sarcoidosis with dendriform ossification: Diagnostic and pathological insights

Hannah Smith  1 , Konstantin Shilo  1 , Arindam Singha  1
Affiliations

Pulmonary sarcoidosis with dendriform ossification: Diagnostic and pathological insights

Hannah Smith et al. Sarcoidosis Vasc Diffuse Lung Dis. .

Abstract

Pulmonary ossification is the histologic finding of mature bone with or without marrow elements within pulmonary tissue. The mechanism of formation is incompletely understood but thought to include metaplastic transformation of pulmonary fibroblasts to osteoblasts secondary to some form of chronic insult and the resulting inflammation from this insult. There are two classifications of pulmonary ossification, nodular and diffuse, based on histologic features. Management of pulmonary ossification is typically supportive, with treatment of the underlying process if one is identified. Here, we describe a man with known pulmonary sarcoidosis previously considered stable who presented with worsening dyspnea and was found to have pulmonary ossification and active cardiac and pulmonary sarcoidosis.

PubMed Disclaimer

Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

Figures

Figure 1.
Figure 1.
CT chest with bibasilar calcified densities.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Terasaki F, Azuma A, Anzai T, et al. JCS 2016 guideline on diagnosis and treatment of cardiac sarcoidosis - digest version. Circ J Off J Jpn Circ Soc. 2019 Oct 25;83(11):2329–88. doi: 10.1253/circj.CJ-19-0508. - PubMed
    1. Chan ED, Morales DV, Welsh CH, McDermott MT, Schwarz MI. Calcium deposition with or without bone formation in the lung. Am J Respir Crit Care Med. 2002 Jun 15;165(12):1654–69. - PubMed
    1. Fried ED, Godwin TA. Extensive diffuse pulmonary ossification. Chest. 1992 Nov;102(5):1614–5. doi: 10.1164/rccm.2108054. - PubMed
    1. Ndimbie OK, Williams CR, Lee MW. Dendriform pulmonary ossification. Arch Pathol Lab Med. 1987 Nov;111(11):1062–4. PMID: 3117014. - PubMed
    1. Fernández Crisosto CA, Quercia Arias O, Bustamante N, Moreno H, Uribe Echevarría A. Diffuse pulmonary ossification associated with idiopathic pulmonary fibrosis. Arch Bronconeumol. 2004 Dec;40(12):595–8. doi: 10.1016/s1579-2129(06)60380-7. - PubMed

LinkOut - more resources