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Review
. 2025 Apr 24;47(5):298.
doi: 10.3390/cimb47050298.

Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up

Francesco Giuseppe Martire  1 , Eugenia Costantini  1 , Claudia D'Abate  1 , Giorgia Schettini  1 , Giuseppe Sorrenti  2 , Gabriele Centini  1 , Errico Zupi  1 , Lucia Lazzeri  1
Affiliations
Review

Endometriosis and Adenomyosis: From Pathogenesis to Follow-Up

Francesco Giuseppe Martire et al. Curr Issues Mol Biol. .

Abstract

Endometriosis and adenomyosis are chronic, hormone-dependent disorders. Estrogens, in particular, play a pivotal role in the pathophysiology of these conditions. Understanding the disease mechanisms, including local hyperestrogenism and reduced progesterone sensitivity, is crucial for effective management. Early diagnosis is essential for appropriate therapeutic intervention, with medical hormonal treatment being the first-line approach. It is important to monitor patients over time and tailor hormone therapy to individual needs in order to optimize treatment adherence. Medical therapy not only enhances patients' quality of life but also appears to slow disease progression in terms of both extent and severity. This narrative review aims to explore all aspects of endometriosis and adenomyosis, from pathogenesis to clinical symptoms, with particular emphasis on the role of hormones and the use of medical therapies.

Keywords: adenomyosis; endometriosis; management; pathogenesis; symptoms.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Pathogenesis theories: (A) common pathogenetic factors of endometriosis and adenomyosis; (B) specific pathogenetic factors of adenomyosis; (C) specific pathogenetic factors of endometriosis.
Figure 2
Figure 2
Diagram of management.
See this image and copyright information in PMC

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