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. 2025 Jul 23:e01379.
doi: 10.1002/cbdv.202501379. Online ahead of print.

Chemical Constituents of Anaphalis hancockii Maxim

Guo-Li Li  1 , Zheng Gong  1 , Yi-Lin He  1 , Zhao-Cai Li  2 , Tong Shen  1
Affiliations

Chemical Constituents of Anaphalis hancockii Maxim

Guo-Li Li et al. Chem Biodivers. .

Abstract

Twenty-seven compounds were isolated from Anaphalis hancockii Maxim in Qinghai Province, China, including 7 isobenzofuranones (1-7), 8 flavonoids (8-15), and 12 other compounds (16-27). Compound 1 is a new isobenzofuranone. The structures of the compounds were determined by analyzing their HRESIMS, 1D- and 2D-nuclear magnetic resonance (NMR), electronic circular dichroism (ECD) and comparing them to the reported data. This study is the first report of A. hancockii Maxim's chemical composition, a perennial herb belonging to the genus Anaphalis. Isobenzofuranones are the main bioactive constituents of the genus Anaphalis; thus, seven isobenzofuranones (1-7) were assessed for their antibacterial and antichlamydial activities. Compound 6 showed moderate activity against six different pathogenic fungi. The result suggested that Compound 5 might be a promising class of therapeutic agents for chlamydial infections.

Keywords: Anaphalis hancockii Maxim; antichlamydial activity; antifungal activity; isobenzofuranones.

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References

    1. Flora of China, Editorial Committee of Chinese flora of Chinese Academy of Sciences (Science Press, 1979).
    1. Jiangsu College of New Medicine. A Dictionary of Traditional Chinese Medicines (Shanghai Science and Technology Press, 1977).
    1. Z. Y. Ren, H. Y. Qi, and Y. P. Shi, “Phytochemical Investigation of Anaphalis lactea,” Planta Medica 74 (2008): 859–863.
    1. R. K. Abdullaeva, K. M. Bobakulov, C. Z. Nishanbaev, I. D. Sham′yanov, and N. D. Abdullaev, “Flavonoids and Other Constituents From the Aerial Part of Anaphalis racemifera,” Chemistry of Natural Compounds 52 (2016): 503–504.
    1. A. A. Ahmed, T. A. Hussein, A. A. Mahmoud, et al., “Nor ent Kaurane Diterpenes and Hydroxylactones From Antennaria geyeri and Anaphalis margaritacea,” Phytochemistry 65 (2004): 2539–2543.

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