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. 2025 Sep;196(Pt B):110716.
doi: 10.1016/j.compbiomed.2025.110716. Epub 2025 Jul 22.

DualSwinUnet++: An enhanced Swin-Unet architecture with dual decoders for PTMC segmentation

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Free article

DualSwinUnet++: An enhanced Swin-Unet architecture with dual decoders for PTMC segmentation

Maryam Dialameh et al. Comput Biol Med. 2025 Sep.
Free article

Abstract

Precise segmentation of papillary thyroid microcarcinoma (PTMC) during ultrasound-guided radiofrequency ablation (RFA) is critical for effective treatment but remains challenging due to acoustic artifacts, small lesion size, and anatomical variability. In this study, we propose DualSwinUnet++, a dual-decoder transformer-based architecture designed to enhance PTMC segmentation by incorporating thyroid gland context. DualSwinUnet++ employs independent linear projection heads for each decoder and a residual information flow mechanism that passes intermediate features from the first (thyroid) decoder to the second (PTMC) decoder via concatenation and transformation. These design choices allow the model to condition tumor prediction explicitly on gland morphology without shared gradient interference. Trained on a clinical ultrasound dataset with 691 annotated RFA images and evaluated against state-of-the-art models, DualSwinUnet++ achieves superior Dice and Jaccard scores while maintaining sub-200ms inference latency. The results demonstrate the model's suitability for near real-time surgical assistance and its effectiveness in improving segmentation accuracy in challenging PTMC cases.

Keywords: Dual-decoder architecture; PTMC segmentation; Swin Transformer; Ultrasound imaging.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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