Nontargeted Toxicological/Chemical Analysis in Complex Mixtures for Risk Assessment and Key Driver Discovery

Chunzhen Shi^{1

2

3}, Xiaoxi Yang², Jifu Liu^{1

2

4}, Haijiang Tian², Jie Gao², Yuhao Yan², Guotao Peng⁵, Hua Qin^{6

2}, Meilin Lv^{6

2}, Yanna Liu², Runzeng Liu^{7

2}, Ningbo Geng⁸, Zongwei Cai⁹, Guangbo Qu^{1

2

10

4}, Jiping Chen⁸, Guibin Jiang^{1

2

10

4}

Affiliations

¹ School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
² State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
³ Department of Environmental Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
⁴ University of Chinese Academy of Sciences, Beijing 100049, China.
⁵ College of Environmental Science and Engineering, Key Laboratory of Yangtze River Water Environment, Tongji University, Shanghai 200092, China.
⁶ Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.
⁷ Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China.
⁸ Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
⁹ State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon 999077, Hong Kong SAR, China.
¹⁰ Institute of Environment and Health, Jianghan University, Wuhan 430056, China.

PMID: 40704078
PMCID: PMC12281198
DOI: 10.1021/envhealth.5c00052

Nontargeted Toxicological/Chemical Analysis in Complex Mixtures for Risk Assessment and Key Driver Discovery

Chunzhen Shi et al. Environ Health (Wash). 2025.

. 2025 Mar 27;3(7):701-704.

doi: 10.1021/envhealth.5c00052. eCollection 2025 Jul 18.

Authors

Affiliations

¹ School of Environment, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
² State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
³ Department of Environmental Science and Engineering, Beijing Technology and Business University, Beijing 100048, China.
⁴ University of Chinese Academy of Sciences, Beijing 100049, China.
⁵ College of Environmental Science and Engineering, Key Laboratory of Yangtze River Water Environment, Tongji University, Shanghai 200092, China.
⁶ Research Center for Analytical Sciences, Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.
⁷ Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China.
⁸ Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China.
⁹ State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Kowloon 999077, Hong Kong SAR, China.
¹⁰ Institute of Environment and Health, Jianghan University, Wuhan 430056, China.

PMID: 40704078
PMCID: PMC12281198
DOI: 10.1021/envhealth.5c00052

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Figures

1
Workflow of NTTA for risk assessment of complex mixtures

See this image and copyright information in PMC

References

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1. Chen Q., Lian X., An J., Geng N., Zhang H., Challis J. K., Luo Y., Liu Y., Su G., Xie Y., Li Y., Liu Z., Shen Y., Giesy J. P., Gong Y.. Life Cycle Exposure to Environmentally Relevant Concentrations of Diphenyl Phosphate (DPhP) Inhibits Growth and Energy Metabolism of Zebrafish in a Sex-Specific Manner. Environ. Sci. Technol. 2021;55(19):13122–13131. doi: 10.1021/acs.est.1c03948. - DOI - PubMed

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Nontargeted Toxicological/Chemical Analysis in Complex Mixtures for Risk Assessment and Key Driver Discovery

Affiliations

Nontargeted Toxicological/Chemical Analysis in Complex Mixtures for Risk Assessment and Key Driver Discovery

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Affiliations

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References

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