Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 24.
doi: 10.1097/SLA.0000000000006854. Online ahead of print.

Perioperative Outcomes in Open Versus Minimally Invasive Gastrectomy For Gastric Cancer: A European Multicenter Study Based on the GASTRODATA Registry

Maria Bencivenga  1 , Kammy Keywani  2   3 , Lorena Torroni  4 , Federica Filippini  1 , Simone Giacopuzzi  1 , Giuseppe Verlato  4 , Arnulf Hoelscher  5 , Domenico D'ugo  6 , Guillaume Piessen  7 , Bas Wijnhoven  8 , Paul Schneider  9 , Manuel Pera  10 , Uberto Fumagalli Romario  11 , Piotr Kołodziejczyk  12 , Karol Rawicz-Pruszynski  13 , Johanna Van Sandick  14 , Lucio Lara Santos  15 , William Allum  16 , Riccardo Rosati  17 , Andrew Davies  18 , Daniel Reim  19 , Stefan Moenig  20 , Ines Gockel  21 , Gian Luca Baiocchi  22 , Paulo Matos Da Costa  23 , Rossella Reddavid  24 , Wojciech Kielan  25 , Carlotta Fiammenghi  26 , Mark van Berge Henegouwen  2   3 , Giovanni De Manzoni  1 , Paolo Morgagni  27 , Suzanne Gisbertz  2   3
Affiliations

Perioperative Outcomes in Open Versus Minimally Invasive Gastrectomy For Gastric Cancer: A European Multicenter Study Based on the GASTRODATA Registry

Maria Bencivenga et al. Ann Surg. .

Abstract

Objective: To evaluate morbidity and mortality after minimally invasive (MIG) versus open gastrectomy (OG) for gastric cancer (GC) in a large European population, with a subgroup analysis comparing total and subtotal gastrectomy.

Summary background data: Real-world European studies comparing postoperative outcomes between MIG and OG are lacking.

Methods: This retrospective study included GC patients undergoing curative-intent gastrectomy between 2017 and 2021 at 24 high-volume European centers participating in the GASTRODATA registry. The primary outcome was the perioperative complication rate after MIG versus OG. Propensity score matching (PSM) was performed to adjust for potential confounders.

Results: Of 2430 patients, 1,800 (74%) underwent OG and 630 (26%) MIG. MIG was performed in patients with smaller tumors, earlier stages, and less frequently receiving neoadjuvant treatment (P<0.001). MIG was associated with higher R0 resection rate (96.5% vs. 92.4% in OG), shorter hospital stay, lower perioperative complication rate (23.0% vs. 31.6%, P<0.001), and reduced 30-day and 90-day mortality rates (1.6% vs. 3.3%, [P=0.026] and 1.9% vs. 4.7%, [P=0.001], respectively). In sub-group analysis, MIG had fewer perioperative complications in subtotal (17.9% vs. 25.3%, P=0.005), but not total gastrectomy (31.5% vs. 36.1%, P=0.201). After PSM, MIG remaind significantly associated with lower perioperative complication rates compared to OG only in subtotal (OR=0.49, 95% CI, 0.30-0.80; P=0.005), but not in total gastrectomy (OR=1.15, 95% CI, 0.62-2.17; P=0.645).

Conclusions: Minimally invasive subtotal gastrectomy was associated with fewer perioperative complications than OG, while this association was not observed for total gastrectomy. Minimally invasive subtotal gastrectomy should be considered a viable option in specialized European centers.

Keywords: gastric cancer; minimal invasive; perioperative outcomes.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: MIvanBH declares consultancies for Johnson and Johnson, Stryker, Boston Scientific, Intuitive and Medtronic. All fees paid to institution. The remaining authors have no conflicts of interest to declare.

LinkOut - more resources