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. 2025 Aug 8;27(31):8464-8469.
doi: 10.1021/acs.orglett.5c02294. Epub 2025 Jul 24.

Synthesis of Cyclobuta[ b]acetylindolines via Gold Photocatalysis

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Synthesis of Cyclobuta[ b]acetylindolines via Gold Photocatalysis

Nestor Bracho Pozsoni et al. Org Lett. .

Abstract

The [2 + 2] cycloaddition reaction constitutes a powerful tool for the construction of cyclobutane-fused scaffolds. A protocol for the intermolecular cycloaddition of 1-acetylindoles was developed where [Au(SIPr)Cbz] has proven indispensable for this purpose, while conventional photocatalysts, such as iridium and organic photosensitizers, have shown limited efficiency. Our findings unlocked the synthesis of cyclobutane-fused indolines, without any required substituent at the C2 or C3 position.

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