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. 2025 Jul 24;45(1):315.
doi: 10.1007/s10792-025-03680-6.

Systemic inflammatory response index as a predictive biomarker for Irvine-Gass syndrome

Serdar Bilici  1 , Tuba Gültekin Erol  2 , Numan Küçük  2 , Suat Hayri Uğurbaş  2
Affiliations

Systemic inflammatory response index as a predictive biomarker for Irvine-Gass syndrome

Serdar Bilici et al. Int Ophthalmol. .

Abstract

Purpose: To evaluate systemic inflammatory marker levels in Irvine-Gass Syndrome (IGS) cases and to compare with uncomplicated cataract (control) cases.

Methods: Medical records of 25 IGS cases and 30 control cases were retrospectively analyzed. Levels of neutrophils, monocytes, lymphocytes, and thrombocytes were obtained from blood samples. Systemic inflammatory markers, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated and compared between the two groups. In case of significant difference presence, the receiver operating characteristic curve (ROC) analysis was performed to determine the best cutoff value of systemic inflammatory markers in IGS.

Results: The medians (min-max) of NLR, PLR, SII, and SIRI were 2.59 (0.13-16.50), 118.42 (5.49-297.69), 525.18 (22.5-3217.5), and 1.44 (0.06-10.11) in IGS group; 1.62 (0.93-8.50), 98.69 (70.0-400.0), 380.60 (161.0-2040.0), and 0.79 (0.37-5.10) in control group, respectively. SIRI was significantly higher in the IGS group (p = 0.036) in comparison to the control group. NLR, PLR, and SII were also found higher in the IGS group, but this difference couldn't reach statistical significance level (p = 0.101, p = 0.600, and p = 0.176, respectively). The ROC analysis revealed that the area under the curve for SIRI to distinguish IGS found to be 0.665. The best cutoff value of SIRI was 0.95, with a sensitivity of 64% and specificity 73%.

Conclusion: Higher levels of SIRI in IGS cases may indicate the potential association between subclinical systemic inflammation and pseudophakic cystoid edema formation. The current results highlight the potential utility of SIRI as a predictive factor for IGS following cataract surgery.

Keywords: Cataract surgery; Irvine-Gass syndrome; Optical coherence tomography; Pseudophakic cystoid macular edema; Systemic inflammatory response index.

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Conflict of interest statement

Declarations. Conflict of interests: The authors declare no competing interests. Ethics approval and consent to participate: This study received approval from the Ethics Committee of Zonguldak University Faculty of Medicine (2024/07–16) and was conducted in accordance with the principles of the Declaration of Helsinki. Due to the retrospective nature of the study, the requirement for written informed consent was waived by the Ethics Committee.

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