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Case Reports
. 2025 Jul 1;73(4):776-780.
doi: 10.4103/neurol-india.Neurol-India-D-24-00355. Epub 2025 Jul 24.

Malignant Transformation of Tentorial Schwannoma

T P Waseem Ahamed  1 , Ved P Maurya  1 , Lily Pal  2 , Vivek Singh  3 , Arun K Srivastava  1
Affiliations
Free article
Case Reports

Malignant Transformation of Tentorial Schwannoma

T P Waseem Ahamed et al. Neurol India. .
Free article

Abstract

Schwannomas are benign tumors derived from Schwann cells, usually seen in the peripheral nervous system. 6.8%-8.0% of all intracranial tumors are accounted by intracranial schwannomas. 90% of these arise from the eighth cranial nerve, less frequently from the fifth, seventh, and twelfth cranial nerves. Schwannomas of the central nervous system [CNS] not arising from cranial nerves are rare. The genesis of these schwannomas in these unusual locations is still controversial since Schwann cells are not a natural component of the CNS. Only 18 tentorial schwannoma [TS] cases have been reported. Interestingly, this is the first reported case of a tentorial schwannoma transforming into a malignant peripheral nerve sheath tumor [MPNST]. We present the case of a 45-year-old gentleman with a giant TS with supra- and infratentorial growth, without any features of neurofibromatosis, and unusual recurrence on follow-up.

Keywords: MPNST; Meningioma; Schwannoma; tentorial.

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