Beyond the native repertoire

Grant H Hickok^{1

2}, Ingunn M Stromnes^{1

2

3

4}

Affiliations

¹ Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
² Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
³ Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA.
⁴ Center for Genome Engineering, University of Minnesota Medical School, Minneapolis, MN, USA.

Comment

Grant H Hickok et al. Science. 2025.

. 2025 Jul 24;389(6758):349-351.

doi: 10.1126/science.adz6423. Epub 2025 Jul 24.

Grant H Hickok^{1

2}, Ingunn M Stromnes^{1

2

3

4}

¹ Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
² Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
³ Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA.
⁴ Center for Genome Engineering, University of Minnesota Medical School, Minneapolis, MN, USA.

Abstract

Design of T cell receptors by artificial intelligence is poised to accelerate cancer immunotherapy.

Design of high-specificity binders for peptide-MHC-I complexes.
Liu B, Greenwood NF, Bonzanini JE, Motmaen A, Meyerberg J, Dao T, Xiang X, Ault R, Sharp J, Wang C, Visani GM, Vafeados DK, Roullier N, Nourmohammad A, Scheinberg DA, Garcia KC, Baker D. Liu B, et al. Science. 2025 Jul 24;389(6758):386-391. doi: 10.1126/science.adv0185. Epub 2025 Jul 24. Science. 2025. PMID: 40705892