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. 2025 Jul 23;113(14):2215-2217.
doi: 10.1016/j.neuron.2025.06.024.

A p16 pathway to prevention: Senescence as a driver of tau-mediated neurodegeneration

Jeff Y L Lam  1 , Kai Wang  1 , Guojun Bu  2
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A p16 pathway to prevention: Senescence as a driver of tau-mediated neurodegeneration

Jeff Y L Lam et al. Neuron. .

Abstract

In this issue of Neuron, Graves et al.1 report that genetically reducing senescent cells by deleting p16 in a tauopathy mouse model significantly lessens tau pathology, neurovascular dysfunction, and behavioral deficits. Their study highlights the crucial role of p16-dependent senescence in microglia and endothelial cells as active drivers of neurodegeneration.

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Conflict of interest statement

Declaration of interests G.B. consults for SciNeuro Pharmaceuticals.

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