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Review
. 2025 Jul 24;23(1):822.
doi: 10.1186/s12967-025-06760-4.

Exploring UBASH3A: from immune regulation to autoimmune diseases

Meng Zhou #  1 , Fangzhou Sun #  2 , Zhenguo Zhao  3 , Haili Qian  2 , Ying Zhang  4 , Yan Song  5
Affiliations
Review

Exploring UBASH3A: from immune regulation to autoimmune diseases

Meng Zhou et al. J Transl Med. .

Abstract

UBASH3A, also known as TULA or STS-2, is a lymphoid protein that has recently emerged as a novel regulator of T-cell activation and function. It used to be discussed as a member of the UBASH3/TULA/STS family to study the unique triple domain structure and protein‒protein interactions. In this review, we focus on the multifaceted regulatory roles of UBASH3A in biological processes within T cells. Furthermore, genetic variants in UBASH3A have been linked to at least five autoimmune phenotypes. Therefore, a broader understanding of the regulatory effects of UBASH3A in innate immunity and adaptive immunity could enable further improvements in the treatment of autoimmune disorders, antimicrobial therapy, and cancer immunotherapy.

Keywords: Autoimmune disease; CLIP4; Infectious disease; STS-2; TULA; UBASH3A.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

Figures

Fig. 1
Fig. 1
Structural domains and activities of UBASH3A
Fig. 2
Fig. 2
Biological functions and effects of UBASH3A in T cells
See this image and copyright information in PMC

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