Correction to: Synergistic actions of corticosterone and BDNF on rat hippocampal LTP

Jonathan S Thacker^{1

2

3

4}, Liam T Ralph^#^{1

2

3}, Laura Koek^#^{1

3}, Aram Abbasian^#^{1

3}, Luis B Bettio⁴, Ashleigh E Smith^{5

6}, John Georgiou^{1

2}, Brian R Christie^{4

7}, Graham L Collingridge^{8

9

10}

Affiliations

¹ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada.
² Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
³ Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
⁴ Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
⁵ Alliance for Research in Exercise Nutrition and Activity (ARENA) Research Group, Division of Health Sciences, University of South Australia, Adelaide, Australia.
⁶ Behaviour, Brain, and Body (BBB) Research Group, Division of Health Science, University of South Australia, Adelaide, Australia.
⁷ Island Medical Program, University of British Columbia, Victoria, BC, Canada.
⁸ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada. Collingridge@lunenfeld.ca.
⁹ Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Collingridge@lunenfeld.ca.
¹⁰ Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Collingridge@lunenfeld.ca.

^# Contributed equally.

PMID: 40708024
PMCID: PMC12291325
DOI: 10.1186/s13041-025-01234-6

Published Erratum

Correction to: Synergistic actions of corticosterone and BDNF on rat hippocampal LTP

Jonathan S Thacker et al. Mol Brain. 2025.

. 2025 Jul 24;18(1):67.

doi: 10.1186/s13041-025-01234-6.

Authors

Affiliations

¹ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada.
² Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
³ Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
⁴ Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.
⁵ Alliance for Research in Exercise Nutrition and Activity (ARENA) Research Group, Division of Health Sciences, University of South Australia, Adelaide, Australia.
⁶ Behaviour, Brain, and Body (BBB) Research Group, Division of Health Science, University of South Australia, Adelaide, Australia.
⁷ Island Medical Program, University of British Columbia, Victoria, BC, Canada.
⁸ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, ON, M5G 1X5, Canada. Collingridge@lunenfeld.ca.
⁹ Tanz Centre for Research in Neurodegenerative Diseases, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Collingridge@lunenfeld.ca.
¹⁰ Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Collingridge@lunenfeld.ca.

^# Contributed equally.

PMID: 40708024
PMCID: PMC12291325
DOI: 10.1186/s13041-025-01234-6

No abstract available

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Figures

**Fig. 1**
Enhanced LTP and phosphorylation of PKA following combined application of CORT and BDNF. **(A)** CA3-CA1 5-min average fEPSP synaptic traces from representative CTRL, CORT, BDNF, CORT + BDNF experiments (B-D, respectively) sampled at baseline ① (dashed line) and 60 min after cTBS induc-tion ② (solid line). **(B-D)**Time course of synaptic responses for each of CORT **(B)**, BDNF **(C)**, and CORT + BDNF **(D)**. Three black arrows represent the cTBS conditioning stimulus. Solid grey bar represents compound (as specified) wash-on period (30 min). **(E-G)** LTP quantification revealed significant LTP enhancement using a one way-ANOVA (F(3,52) = 20.68, p = 0.0001) for BDNF (F; p = 0.0002) and CORT + BDNF (G; p < 0.0001) treatment but not CORT (E; p = 0.97) (female open circle, male closed circle). CORT + BDNF was significantly enhance compare to BDNF alone (**F vs. G**: mean difference = + 21 ± 8%, t(52) = 2.6, p = 0.01) **(H-J)** Exemplar western blots (right) and quantification (left) of phosphorylated PKA (T197) relative to total PKA levels (normalized to vehicle, VEH) after 30 min application of CORT (H), BDNF (I), or CORT + BDNF (J), respectively. CORT + BDNF was the only condition to display an increased pPKA signal (p = 0.01). The two lanes refer to VEH (-) versus compound (+) application. Connected lines refer to data from pairs of pooled hippocampal slices obtained from the same animal

See this image and copyright information in PMC

Erratum for

Synergistic actions of corticosterone and BDNF on rat hippocampal LTP.
Thacker JS, Ralph LT, Koek L, Abbasian A, Bettio LB, Smith AE, Georgiou J, Christie BR, Collingridge GL. Thacker JS, et al. Mol Brain. 2025 May 12;18(1):42. doi: 10.1186/s13041-025-01213-x. Mol Brain. 2025. PMID: 40355868 Free PMC article.

References

1. Thacker JS, Ralph LT, Koek L, et al. Synergistic actions of corticosterone and BDNF on rat hippocampal LTP. Mol Brain. 2025;18:42. 10.1186/s13041-025-01213-x. - PMC - PubMed

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Correction to: Synergistic actions of corticosterone and BDNF on rat hippocampal LTP

Affiliations

Correction to: Synergistic actions of corticosterone and BDNF on rat hippocampal LTP

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