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. 2025 Sep;107(2):494-495.
doi: 10.1177/13872877251361051. Epub 2025 Sep 1.

Safety of switching from lecanemab to donanemab in 20 consecutive patients with Alzheimer's disease

Heii Arai  1 , Satoko Aiba  1 , Reiko Arai  1
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Safety of switching from lecanemab to donanemab in 20 consecutive patients with Alzheimer's disease

Heii Arai et al. J Alzheimers Dis. 2025 Sep.

Abstract

We retrospectively reviewed 20 consecutive patients with Alzheimer's disease who switched from lecanemab to donanemab. No new amyloid-related imaging abnormalities (ARIA) or significant adverse events were observed during the first five donanemab infusions. Prior exposure to lecanemab may reduce ARIA risk. Cognitive function remained stable. These preliminary observations suggest that switching between anti-amyloid therapies may be safe in the short term, though larger prospective studies are warranted.

Keywords: Alzheimer's disease; dementia; immunotherapy.

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Conflict of interest statement

Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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