Meeting Report on an Integrated Research Agenda for Mosquito-Borne Arboviruses

Angela K Ulrich¹, Nicolina M Moua¹, Alison Mack², Natsuko Imai-Eaton³, J Erin Staples⁴, Angela J Mehr¹, Julia T Ostrowsky¹, Tabitha Leighton¹, Ana Cehovin³, Petra C Fay³, Josephine P Golding³, Emma Maynard³, Luke Alphey⁵, Diana P Rojas Alvarez⁶, Lark L Coffey⁷, Nuno R Faria⁸, Rafael Maciel-de-Freitas^{9

10}, Kevin Maringer¹¹, Kris A Murray¹², Henrik Salje¹³, Rosemary Sang¹⁴, Pedro F C Vasconcelos^{15

16}, Yee-Sin Leo^{17

18}, Steven P Sinkins¹⁹, Jocelyne Neto de Vasconcelos²⁰, Samuel K Dadzie²¹, Eva Harris²², Thais H Dos Santos²³, Raman Velayudhan⁶, Jurai Wongsawat²⁴, Michael T Osterholm¹, Eve M Lackritz¹

Affiliations

¹ Center for Infectious Disease Research and Policy (CIDRAP), University of Minnesota, Minneapolis, Minnesota, USA.
² Independent Consultant to CIDRAP, Wilmington, Delaware, USA.
³ Wellcome Trust, London, UK.
⁴ Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
⁵ Department of Biology, University of York, York, UK.
⁶ World Health Organization, Geneva, Switzerland.
⁷ School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
⁸ MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
⁹ Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
¹⁰ Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
¹¹ The Pirbright Institute, Pirbright, UK.
¹² Centre on Climate Change and Planetary Health, Medical Research Council Unit The Gambia, London School of Hygiene & Tropical Medicine, London, UK.
¹³ Department of Genetics, University of Cambridge, Cambridge, UK.
¹⁴ International Centre of Insect Physiology and Ecology, Nairobi, Kenya.
¹⁵ Universidade do Estado do Pará, Belém, Pará, Brazil.
¹⁶ Instituto Evandro Chagas, Ananindeua, Pará, Brazil.
¹⁷ National Healthcare Group, National Centre for Infectious Diseases, Singapore.
¹⁸ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
¹⁹ Medical Research Council (MRC) University of Glasgow Centre for Virus Research, Glasgow, UK.
²⁰ Centro de Investigação em Saúde de Angola, Caxito, Angola.
²¹ Noguchi Memorial Institute for Medical Research, Accra, Ghana.
²² Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, USA.
²³ Pan American Health Organization, Washington, DC, USA.
²⁴ Department of Disease Control, Ministry of Public Health, Bamrasnaradura Infectious Disease Institute, Nonthaburi, Thailand.

PMID: 40708628
PMCID: PMC12287632
DOI: 10.1093/ofid/ofaf395

Meeting Report on an Integrated Research Agenda for Mosquito-Borne Arboviruses

Angela K Ulrich et al. Open Forum Infect Dis. 2025.

. 2025 Jul 9;12(7):ofaf395.

doi: 10.1093/ofid/ofaf395. eCollection 2025 Jul.

Authors

Affiliations

¹ Center for Infectious Disease Research and Policy (CIDRAP), University of Minnesota, Minneapolis, Minnesota, USA.
² Independent Consultant to CIDRAP, Wilmington, Delaware, USA.
³ Wellcome Trust, London, UK.
⁴ Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
⁵ Department of Biology, University of York, York, UK.
⁶ World Health Organization, Geneva, Switzerland.
⁷ School of Veterinary Medicine, University of California, Davis, Davis, California, USA.
⁸ MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
⁹ Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
¹⁰ Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
¹¹ The Pirbright Institute, Pirbright, UK.
¹² Centre on Climate Change and Planetary Health, Medical Research Council Unit The Gambia, London School of Hygiene & Tropical Medicine, London, UK.
¹³ Department of Genetics, University of Cambridge, Cambridge, UK.
¹⁴ International Centre of Insect Physiology and Ecology, Nairobi, Kenya.
¹⁵ Universidade do Estado do Pará, Belém, Pará, Brazil.
¹⁶ Instituto Evandro Chagas, Ananindeua, Pará, Brazil.
¹⁷ National Healthcare Group, National Centre for Infectious Diseases, Singapore.
¹⁸ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
¹⁹ Medical Research Council (MRC) University of Glasgow Centre for Virus Research, Glasgow, UK.
²⁰ Centro de Investigação em Saúde de Angola, Caxito, Angola.
²¹ Noguchi Memorial Institute for Medical Research, Accra, Ghana.
²² Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, USA.
²³ Pan American Health Organization, Washington, DC, USA.
²⁴ Department of Disease Control, Ministry of Public Health, Bamrasnaradura Infectious Disease Institute, Nonthaburi, Thailand.

PMID: 40708628
PMCID: PMC12287632
DOI: 10.1093/ofid/ofaf395

Abstract

The emergence and re-emergence of mosquito-borne arbovirus (MBV) diseases pose a rapidly expanding global health threat fueled by the convergence of multiple ecologic, economic, and social factors, including climate change, land use, poverty, deficiencies of water storage and sanitation, and limitations of vector control programs. On December 6, 2023, the Wellcome Trust and the University of Minnesota's Center for Infectious Disease Research and Policy held a meeting titled "An integrated approach to mosquito-borne arboviruses: a priority research agenda." The meeting comprised presentations, panels, and facilitated discussions aimed at describing the state of the field, highlighting recent accomplishments, identifying novel strategies, and defining priority research goals and approaches for addressing MBV disease preparedness and response. This report summarizes meeting discussions in 3 key areas: the changing epidemiology of MBV disease, current and potential transmission- and disease-monitoring strategies, and evolutionary impacts on disease burden and transmission. It concludes with a list of priority strategies for research and investment in MBV disease prevention, preparedness, and control. To prepare for future epidemics of MBV diseases, research and policy will benefit from a multipathogen approach to MBVs. Building on existing knowledge and systems, these efforts must address social and ecological factors and connect with other global health agendas.

Keywords: disease control; disease prevention; mosquito-borne arbovirus; policy; research.

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Conflict of interest statement

Potential conflicts of interest. A.K.U., A.J.M., J.O., T.L., M.T.O., E.M.L., E.S., L.L.C., R.M.F., H.S., J.W., L.Y.S., S.P.S., E.H., and K.A.M. declare Wellcome-supported participant travel to the arbovirus meeting that this manuscript summarizes. A.K.U., N.M.M., A.J.M., J.O., T.L., M.T.O., and E.M.L. report a grant from the Wellcome Trust to support planning of the arbovirus meeting and writing of the meeting report. A.M. received sponsored travel to attend the meeting that the manuscript summarizes. N.I.-E., A.C., P.F., J.G., and E.M. are employees of Wellcome. Wellcome supported organization of the meeting and its reports. L.A. is a paid adviser to Biocentis Ltd, a member of the UK Scientific Advisory Committee on Genetic Modification (Contained Use), an adviser to Synvect Inc. with equity interest, and a recipient of a Wellcome grant (number 226721/Z/22/Z). K.M. reports grants to the Pirbright Institute to support salary and research from the Biotechnology and Biological Sciences Research Council; Medical Research Council (UK); and National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH); and is a member of the Dengue Advisory Committee for the International Society for Neglected Tropical Diseases. E.H. reports NIH research support awarded to the institution. All other authors report no potential conflicts.

Figures

**Figure 1.**
Mosquito-borne arboviral diseases are impacted by several interacting factors including climate; ecology; host factors; human interface and actions such as urbanization, migration, poverty, care seeking, clinical awareness, and testing; and vectors, including vector control methods. Each factor has representative illustrative icons with arrows between factors to indicate interaction.

See this image and copyright information in PMC

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Meeting Report on an Integrated Research Agenda for Mosquito-Borne Arboviruses

Affiliations

Meeting Report on an Integrated Research Agenda for Mosquito-Borne Arboviruses

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources