Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2025 Jul 10:16:1618513.
doi: 10.3389/fpsyg.2025.1618513. eCollection 2025.

Psychoneurological symptom clusters in patients with first stroke and relationship with inflammatory markers: a latent profile analysis

Yuanyuan Tang  1   2 , Gudi Jiang  1 , Meilan Jin  3 , Shanyu Wu  1 , Jinji Wu  1
Affiliations

Psychoneurological symptom clusters in patients with first stroke and relationship with inflammatory markers: a latent profile analysis

Yuanyuan Tang et al. Front Psychol. .

Abstract

Objective: This study aimed to explore the relationship between psychoneurological symptom clusters and inflammatory markers in patients with a first stroke.

Methods: This study investigated 227 patients with a first stroke using general information questionnaires, Numerical Rating Scale, Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Scale, Ascertain Dementia 8, Fatigue Severity Scale, and Stroke-Specific Quality of Life. Data analysis included latent profile analysis, one-way analysis of variance, and unordered multicategorical logistic analysis.

Results: The psychoneurological symptom clusters of first-stroke patients were categorized into three latent profiles: the low symptom group (45.2%), moderate symptom group (36.7%), and high symptom group (18.1%). Logistic regression analyses showed that younger age, female, higher National Institute of Health Stroke Scale score, higher interleukin-6 level, and higher hypersensitive C-reactive protein level were major predictive factors for the moderate and high symptom groups.

Conclusion: Three latent profiles of psychoneurological symptom clusters exist in patients with a first stroke and are associated with markers of inflammation (interleukin-6 and hypersensitive C-reactive protein), thereby affecting their quality of life. These findings extend previous research on psychoneurological symptom clusters in stroke. Further exploration of a broader range of inflammatory markers and psychoneurological symptom clusters is necessary to advance symptom management.

Keywords: a latent profile analysis; first stroke; inflammatory markers; psychoneurological symptom clusters; quality of life.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Potential profiling of psychoneurological symptom clusters in the first stroke patients.
See this image and copyright information in PMC

References

    1. Airaksinen J., Gluschkoff K., Kivimäki M., Jokela M. (2020). Connectivity of depression symptoms before and after diagnosis of a chronic disease: a network analysis in the U.S. health and retirement study. J. Affect. Disord. 266, 230–234. doi: 10.1016/j.jad.2020.01.170, PMID: - DOI - PubMed
    1. Al-Bashaireh A. M., Khraisat O., Alnazly E. K., Aldiqs M. (2021). Inflammatory markers, metabolic profile, and Psychoneurological symptoms in women with breast Cancer: a literature review. Cureus 13:e19953. doi: 10.7759/cureus.19953, PMID: - DOI - PMC - PubMed
    1. Bach A., Conzen C., Schubert G. A., Bleilevens C., Lindauer U. (2019). Acute changes of pro-inflammatory markers and corticosterone in experimental subarachnoid haemorrhage: a prerequisite for severity assessment. PLoS One 14:e0220467. doi: 10.1371/journal.pone.0220467, PMID: - DOI - PMC - PubMed
    1. Bogosian A., Hurt C. S., Hindle J. V., McCracken L. M., Vasconcelos E Sa D. A., Axell S., et al. (2022). Acceptability and feasibility of a mindfulness intervention delivered via videoconferencing for people with Parkinson’s. J. Geriatr. Psychiatry Neurol. 35, 155–167. doi: 10.1177/0891988720988901, PMID: - DOI - PMC - PubMed
    1. Buonacera A., Stancanelli B., Colaci M., Malatino L. (2022). Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases. Int. J. Mol. Sci. 23:363. doi: 10.3390/ijms2307363 - DOI - PMC - PubMed

LinkOut - more resources