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. 2025 Jul 14;13(7):220.
doi: 10.3390/diseases13070220.

Myxoid Liposarcoma of the Thigh in Early Puerperium-Rare Case Report and Narrative Review

Tomasz Machałowski  1 , Piotr Gutowski  2 , Edyta Zagrodnik  3 , Aleksandra Godlewska  1 , Katarzyna Śmieja  1 , Oliwia Kawałek  1 , Anna Grzymała-Figura  1 , Sylwester Michał Ciećwież  1 , Katarzyna Gross-Kępińska  4 , Małgorzata Szczuko  5 , Maciej Ziętek  1
Affiliations

Myxoid Liposarcoma of the Thigh in Early Puerperium-Rare Case Report and Narrative Review

Tomasz Machałowski et al. Diseases. .

Abstract

Background: Liposarcoma (LPS) is a rare malignant tumor, but it is also one of the most common adult soft-tissue sarcomas. Myxoid liposarcoma (MLPS) accounts for 30% of all LPS cases. Diagnosis during pregnancy and the puerperium is very rarely reported, and only a few cases have been reported in the thigh.

Case presentation: We report the case of a 36-year-old female patient on the 11th day of the puerperium after a cesarean section. The patient presented to the gynecology ward owing to the sudden appearance of a tumor in the medial part of her right thigh. The lesion was non-painful, mobile, soft, approximately 20 cm in diameter, and protruded above the level of the rest of the thigh surface. A suspicion of hematoma was raised. The final diagnosis was high-grade MLPS.

Conclusions: An MLPS diagnosis is uncommon in female patients and even rarer during pregnancy. This case represents a novel occurrence, as the first instance in which symptoms manifested during the puerperium. Proper treatment and early detection could improve disease outcomes.

Keywords: myxoid liposarcoma; pregnancy; puerperium; sarcoma.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Ultrasound image of right thigh tumor (GE Voluson S10 Expert; BT16, 2019; 3/4D convex probe RAB6-RS) Red circle- tumor.
Figure 2
Figure 2
Picture of the tumor’s location and axial/coronal computed tomography imaging of a massive right thigh tumor—red circle (SOMATOM Edge Plus 128-layer CT scanner).
Figure 3
Figure 3
MRI imaging of a massive right thigh tumor. (A) shows a coronal T2-weighted image, and (B) shows an axial contrast-enhanced T1-weighted image. The signal intensity of the tumor is very bright on the T2-weighted image (A), suggesting that the tumor contains myxoid parts. The contrast-enhanced T1-weighted image shows a strong contrast enhancement of the tumor (B) (Philips MR 7700, 3.0 T; Philips, Cambridge, USA).
Figure 4
Figure 4
Microscopic image from the Department of Soft Tissue/Bone Sarcoma and Melanoma Maria Skłodowska-Curie Memorial Cancer Center in Warsaw. High-grade MLPS FNCLCC (Federation Nationale de Centros de Lutte Contre le Cancer) Grade 2 (G2). (A) H&E (hematoxylin and eosin steins) 20× (B) H&E 40×.
Figure 5
Figure 5
Individual therapeutic intervention scheme.
See this image and copyright information in PMC

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